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Featured Articles

  • February 13, 2018

    Preventing Pressure Ulcers in Hospitals: A Toolkit for Improving Quality of Care

    Pressure ulcer prevention requires an interdisciplinary approach to care. Some parts of pressure ulcer prevention care are highly routinized, but care must also be tailored to the specific risk profile of each patient. No individual clinician working alone, regardless of how talented, can prevent all pressure ulcers from developing. Rather, pressure ulcer prevention requires activities among many individuals, including the multiple disciplines and multiple teams involved indeveloping and implementing the care plan. To accomplish this coordination, high quality prevention requires an organizational culture and operational practices that promote teamwork and communication, as well as individual expertise. Read More

    Shock Waves Can Help Heal Diabetic Foot Ulcers

    Foot ulcers caused by poor circulation, neuropathy or foot deformities represent one of the most expensive and difficult complications to heal for people with diabetes. Wound centers initially use “standard of care” treatments to clean the wound and remove dead skin along with expensive topical agents and sometimes even honey. Adjunct treatments often are needed to improve the chances of healing diabetes foot ulcers that, once infected, can lead to amputations. Now another safe and effective adjunct treatment has been added to the wound-healing arsenal. Read More

    Lactic Acid Bacteria Could be Key for Accelerated Wound Healing

    Researchers have found a new method to accelerate how wounds heal in humans. A team of scientists from Uppsala University and SLU has discovered that lactic acid bacteria can be transformed into human chemokine-producing vectors to bioengineer the wound microenvironment and greatly accelerate wound closure. The researchers are the first to develop the concept for topical use. The technology could turn out to be disruptive to the field of biologic drugs. A treatment that kick-starts and accelerates wound healing would have a significant impact due to the aging population, occurrence of chronic diseases including diabetes and the global spread of antibiotic resistances. Read More

    Smartphone App Allows Doctors, Nurses to Remotely Monitor Wound Healing

    The healing of postoperative surgical wounds can be effectively monitored with a new smartphone app, new research indicates. The app, called WoundCheck, can be used to send digital images of a post-surgical wound with a short patient-administered questionnaire to monitoring nurses and could help reduce the need for post-surgical patient readmission, researchers report in a study published in the Journal of the American College of Surgeons. The study, conducted at the University of Wisconsin-Madison, indicates that the sending of images by patients can reduce surgical site infections and patient readmissions, and improve patient care. Read More

  • February 7, 2018

    Macrophages May Promote Progression of Systemic Sclerosis, Study Shows

    New research establishes a link between immune cells, known as macrophages, and systemic sclerosis progression. The study showed that gene expression in macrophages from systemic sclerosis patients is altered, including higher activity of the susceptibility gene GSDMA. Previous studies have identified several genes linked to an increased susceptibility to systemic sclerosis, but which cells carried these variants remained poorly understood. Now, an international collaboration identified a group of immune cells – macrophages – as potential perpetrators of disease progression. Read More

    Unexpected Helpers in Wound Healing

    Nerve cells in the skin help wounds to heal. When an injury occurs, cells known as glial cells change into repair cells and disseminate into the wound, where they help the skin to regenerate, researchers from the University of Zurich have shown. There have long been indications that for optimal healing to occur, a tissue needs to be innervated (i.e. supplied with nerves). The reason, however, remained unclear. With the help of an animal model, researchers discovered that fine nerve bundles change drastically if they are injured when a skin wound occurs. Read More

    Safety Board OKs Continuation of Phase 2b Trial of Lanifibranor as a Systemic Sclerosis Treatment

    A data safety monitoring board (DSMB) has recommended that Inventiva continue its Phase 2b clinical trial assessing lanifibranor (previously known as IVA337) for the treatment of diffuse cutaneous scleroderma, after reviewing data gathered in the study to date. The trial, which is now fully enrolled with 145 patients, compares lanifibranor to a placebo. Researchers believe that the treatment has the potential to slow disease progression in people with scleroderma by controlling fibrosis development. Read More

    New Technology for Accelerated Wound Healing Discovered

    Researchers have found a new way of accelerating wound healing. The technology and the mode of action involves using lactic acid bacteria as vectors to produce and deliver a human chemokine on site in the wounds. The research group is the first in the world to have developed the concept for topical use and the technology could turn out to be disruptive to the field of biologic drugs. The potent effect on acceleration of wound healing is demonstrated in healthy mice but also in two models of diabetes, one model of peripheral ischemia as well as in a model using human skin biopsies. Read More

  • January 31, 2018

    Collagen VII Protein Important in Immune Response to Bacteria in EB, Mouse Study Shows

    The systemic administration of collagen VII protein can reduce bacteria in the skin of mice with epidermolysis bullosa (EB), according to a report published in the journal Proceedings of the National Academy of Sciences. The study, “Impaired lymphoid extracellular matrix impedes antibacterial immunity in epidermolysis bullosa,” showed that collagen VII is required in the spleen to support the activity of immune cells and promote their innate defense mechanisms. This finding may help researchers understand why people with epidermolysis bullosa, a rare genetic disease caused by a mutation in the COL7A1 gene — which provides instructions for the protein collagen VII — are more susceptible to developing wound infections. The results may also open new therapeutic avenues to treat EB. Read More

    People With Diabetes Face Increased Risk of Infections

    Diabetes patients have an increased risk of suffering serious infections or death compared to the general public, new research has shown. The study analysed the electronic GP and hospital records of more than 100,000 adults aged 40 to 89 years with a diabetes diagnosis, and compared them to those without a diabetes diagnosis. The researchers estimated that 6% of infection-related hospital admissions, such as for pneumonia, and 12% of infection-related deaths among adults could be attributed to diabetes. Read More

    Iran Unveils Indigenous Polymer Wound Care Dressing, Artificial Vessel

    Iranian scientists have managed to produce an artificial vessel and a type of wound care dressing using polymeric materials. The two technological developments were unveiled in a ceremony attended by the Head of Iran Polymer and Petrochemical Institute (IPPI) Mehdi Nekouhesh. The polymer wound care dressing was invented as part of larger plan to find a treatment for a particular type of skin wounds, a Farsi report by Mehr said. The artificial vessel was the second invention of the Institute’s scientists. The vessel, which is now at the clinical stage, used to be an imported good and is being produced for the first time by IPPI in Iran. Read More

    A Powerful new Weapon Against Drug-Resistant Bacteria was Inspired by the Human Body

    Drug-resistant bacteria are thwarting the world’s last-resort antibiotics, leading scientists to seek new compounds from poisonous frogs, backyard soil bacteria, and other wildlife. Now, scientists have found the makings of an exceptional microbe killer inside us: By tweaking a naturally occurring peptide—a short chain of amino acids—found in the human body, researchers have designed a drug that could wipe out obstinate microbes resistant to all available treatments. When a small subset of bacteria survives antibiotic treatment, an infection can get out of control fast. As these resilient microbes thrive, they can group together on a surface—like a wound or a medical device—and encase themselves in a slimy protective layer known as a biofilm.  Read More

  • January 24, 2018

    Clinical Education Available On-Demand!  "Preventing Surgical Site Infections: Implementing a Multidisciplinary Evidence-Based Strategy."

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    Eye Exam Might Help Spot Poor Circulation in Legs

    Could a routine eye exam some day point to trouble with circulation in the legs? New research suggests it might be possible. Researchers at Johns Hopkins University in Baltimore said changes in the eye's retina may help spot people at risk for a narrowing of the large blood vessels in the legs -- a condition called peripheral artery disease (PAD). After adjusting for common PAD risk factors such as diabetes, the researchers found that people with abnormalities in the tiny blood vessels of the retina had more than double the odds of developing PAD, and nearly 3.5 times the odds of developing its more severe form, critical limb ischemia. Read More

    Pneumatic Compression Promising for Lymphedema

    One treatment session with advanced pneumatic compression is associated with reduced cancer-related head and neck lymphedema. Head and neck lymphedema is a frequent complication of treatment for cancers of the head and neck. Head and neck cancer and its treatment by surgical interventions and/or radiotherapy may obstruct or disrupt lymphatic vessels and damage surrounding soft tissue. The lymphatic disruption and tissue damage leads to an accumulation of fluid in the affected areas. This protein-rich fluid activates chronic inflammatory responses resulting in progressive skin and subcutaneous tissue fibrosis further impairing lymphatic function. Although head and neck lymphedema is associated with substantial symptom burden, functional deterioration, and poor quality of life, it remains underrecognized and undertreated. Read More

    Patient Outcomes After Revascularization Improve in UK

    From 2006 to 2015, overall survival increased and the risk for lower-limb amputation decreased after revascularization in patients with peripheral artery disease in the United Kingdom. The availability of revascularization procedures has changed during the past decade (2006-2015), and with recent developments in endovascular and surgical technology, particularly stents and drug-eluting technologies, less invasive procedures have become more widely used in the United Kingdom and elsewhere. Read More

    Equine Stem Cells May Rein in Bacteria in Skin Wounds

    Researchers with the Cornell University College of Veterinary Medicine are exploring the use of stem cells to treat skin wounds in horses with techniques that may eventually translate into the treatment of human patients. Bacteria often complicate the treatment of chronic skin wounds in people, driving a need for new therapies that reduce bacteria in wounds. Although previous research has explored the therapeutic value of MSCs in healing, few studies have examined the potential for MSCs to inhibit bacterial growth. Read More

    Microbes On The Skin Of Mice Promote Tissue Healing, Immunity

    Beneficial bacteria (link is external) on the skin of lab mice work with the animals’ immune systems to defend against disease-causing microbes and accelerate wound healing, according to new research from scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. Researchers say untangling similar mechanisms in humans may improve approaches to managing skin wounds and treating other damaged tissues. Read More


  • January 17, 2018

    Clinical Education Available On-Demand!  "Preventing Surgical Site Infections: Implementing a Multidisciplinary Evidence-Based Strategy."

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    TCMH is Testing Ground for New Wound Therapy Technology

    Mirragen, developed by Missouri Science and Technology student and ceramic engineer Steve Jung, is a bioactive resorbable glass fiber technology that has been found to help wounds heal faster. As a glass fiber, Mirragen can also be used for wounds with challenging geometries. Bioactive glass has been used since the 1960s to grow bone tissue. The silica used in bioactive glass was not a suitable product for growing soft tissue, but Jung used boron in a glass fiber that was found to help heal soft tissue. The borate-based fiber is sturdy and durable for a period of time, but it also breaks down and dissolves as soft tissue heals. Read More

    FDA Grants Marketing Permission for Diabetic Foot Ulcer Treatment Device

    The FDA has permitted the marketing for the first shock-wave device for the use of treating diabetic foot ulcers, according to an agency press release. The device is intended for treatment of chronic, full-thickness diabetic foot ulcers with wound areas no larger than 16 cm2 extending through the epidermis, dermis, tendon or capsule, without bone exposure. The device is an external system that employs pulses of energy to stimulate the wound and is intended for use in adults aged at least 22 years with diabetic foot ulcers of more than 30 days’ duration. The device should be used along with standard care. Read More

    New Molecular Probes to Allow Non-Destructive Analysis of Bioengineered Cartilage

    A new study describes novel probes that enable non-invasive, non-destructive, direct monitoring of the differentiation of mesenchymal stem cells (MSCs) in real-time during the formation of engineered cartilage to replace damaged or diseased tissue. These molecular probes make it possible to assess the quality of the cartilaginous tissue and its suitability for implantation as it is forming, and to make modifications to enhance the multi-step process of MSC differentiation into chondrocytes "on the go". Read More

    An eNose is Able to Sniff out Bacteria that Cause Soft Tissue Infections

    A recent study conducted at the University of Tampere, Tampere University of Technology, Pirkanmaa Hospital District and Fimlab in Finland has concluded that an electronic nose (eNose) can be used to identify the most common bacteria causing soft tissue infections. A recent study conducted at the University of Tampere, Tampere University of Technology, Pirkanmaa Hospital District and Fimlab in Finland has concluded that an electronic nose (eNose) can be used to identify the most common bacteria causing soft tissue infections. Read More

    Science Fiction and Folk Medicine Inspire Novel Wound Dressings

    A relatively inexpensive egg-based formula and a Star Trek-like plasma patch can accelerate healing of serious and chronic wounds. Inspired in part by Star Trek, his favourite show, Dr. Mahrenholz is bringing the sci-fi use of plasma closer to reality by developing an active plasma dressing for treating chronic wounds. But he warns that the current issues we are experiencing with multidrug-resistant bacteria means that we are on the brink of a return to the Middle Ages in terms of our susceptibility to infection. Read More


  • January 10, 2018

    Clinical Education Available On-Demand!  "Preventing Surgical Site Infections: Implementing a Multidisciplinary Evidence-Based Strategy."

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    Specialist says Cryopreserved Tissue is 'Game Changer' for Diabetic Foot Ulcers

    Thanks to a cutting-edge treatment, Anton not only kept her toes, but also maintained normal movement in her foot. Grafix, cryopreserved human placental tissue, was applied to the surface of Anton's wound. She also received hyperbaric oxygen therapy, a medical treatment in which patients breathe 100 percent oxygen while under pressure in a hyperbaric chamber, and wore a total contact cast to maximize offloading. Read More

    Leishmaniasis in Humans: Drug or Vaccine Therapy?

    Leishmania is an obligate intracellular pathogen that invades phagocytic host cells. Approximately 30 different species of Phlebotomine sand flies can transmit this parasite either anthroponotically or zoonotically through their bites. Leishmaniasis has been reported as one of the most dangerous neglected tropical diseases, second only to malaria in parasitic causes of death. People can carry some species of Leishmania for long periods without becoming ill, and symptoms depend on the form of the disease. Read More

    Using Mechanical Forces to Improve Wound Healing

    To most, an operating room and a manufacturing plant are as different as any two places can be. But not to Dennis Orgill. Orgill showed for the first time how to regenerate both the epidermis and the dermis of the skin. He developed a process of infusing a collagen skin graft — known as a scaffold — with healthy cells to promote regeneration. When applied to the wound, the cell-infused scaffold was found to promote healing. Read More

    Low-Intensity Workouts Help Wound Healing for Diabetics

    Low-power exercise may be the key to speeding wound healing rates in patients with diabetes, a new study suggests. Previous research showed moderate-intensity exercise to improve wound healing in both mice and human subjects, but little was known about the impact different intensities could have on healing rates. Read More

    Stop the Splashes, Spills: How Hospitals can Ensure Safe Disposal of Infectious Fluid Waste

    For clinical leaders on the front lines of healthcare, keeping patients and staff safe is the No. 1 priority. The products and practices that are utilized to support infection prevention are the same products and practices that support the safety of the employee as care is given. If facilities focus on one goal and not the other, they won't realize the desired outcome for patients and healthcare workers. It's critical in today's environment to always address both. Read More