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Featured Articles

  • August 7, 2018

    Three-Minute Thesis: Healing Diabetic Wounds: A Team Approach

    “Every 20 seconds, a limb is amputated because of complications in the delayed healing of chronic diabetic wounds. Understanding the mechanisms behind this delayed healing is key to developing therapies to encourage better healing and prevent the needless loss of limbs to diabetes. This project explores the link between diabetic healing and the decreased presence of a specific cell type, the pericyte, and whether targeting pericytes represents a promising avenue for the treatment of diabetic wounds.”  Read More

    Striking a Balance Between Immunity and Inflammation

    Hookworms infect people mostly in countries where sanitation is poor and people often walk barefoot. Working on a mouse model, a research team has studied the secretion of the immune protein RELMalpha that is triggered in the body, following infection, to protect body tissue. When the researchers knocked out RELMalpha, the mice produced super-killer macrophages that attached to the hookworm in far greater numbers. These macrophages, however, provoked increased tissue damage and inflammation. Read More

    Here’s Why Wounds Heal Faster in the Mouth Than in Other Skin

    Mouth wounds heal faster than injuries to other parts of the skin, and now scientists are learning how the mouth performs its speedy repairs. Some master regulators of gene activity work overtime in the mouth to heal wounds without scarring, researchers report July 25 in Science Translational Medicine. Those regulators — proteins known as SOX2, PITX1, PITX2 and PAX9 — are active in skin cells called keratinocytes in the mouth, but not in skin cells from the arm.  Read More

    Oxygen Therapy: Calls for More Funding Amid Rising Use

    Meet the Tokoroa man who has installed a hyperbaric chamber at home to help his wife's recovery from a stroke. Ian Stewart is championing the use of a treatment involving pressurised oxygen by calling for better access and funding for an increased number of treatments. The treatment involves patients lying inside a pressurised chamber and breathing pure oxygen. In a pressurised environment your lungs can take in more oxygen than would be possible at normal air pressure, which then stimulates growth and healing. Read More

  • July 30, 2018

    Machine Learning Improves Early Accurate Detection of Lymphedema

    Lymphedema, an adverse effect of breast cancer treatment that causes swelling in the arms or legs, occurs in more than 41% of patients within 10 years of their surgery. According to a new study published in mHealth, researchers have developed an efficient way to detect lymphedema with machine learning, a type of artificial intelligence. Lymphedema can be a debilitating adverse effect of breast cancer treatment that can progress to a severe and chronic condition if left untreated. There is no cure for lymphedema, but early detection and treatment can help reduce symptoms and keep it from worsening.  Read More

    Negative Pressure Wound Therapy No Better Than Standard Care For Open Traumatic Wounds

    For open traumatic wounds involving fracture or soft tissue, there is "no clear difference" between standard care and negative pressure wound therapy (NPWT), and the latter is unlikely to be cost-effective, according to a recent Cochrane Review. Four studies on open-fracture wounds found no clear difference between NPWT and standard care. After pooling data on wound infection from four studies of 596 participants with an average follow-up of 30 days, the authors concluded, "It is uncertain whether NPWT at 125 mmHg reduces the risk of wound infection (in open-fracture wounds) compared with standard care (RR, 0.48)," with very low-certainty evidence. Read More

    Immune Cells Produce Wound Healing Factor, Could Lead to New IBD Treatment

    Specific immune cells have the ability to produce a healing factor that can promote wound repair in the intestine, a finding that could lead to new, potential therapeutic treatments for inflammatory bowel disease (IBD), according to a new research study. The research team, led by Georgia State University and the University of Michigan, wanted to understand how a wound heals in the intestine because in IBD, which includes Crohn's disease and ulcerative colitis, damage to the intestinal epithelial barrier allows bacteria in the intestine to go across the barrier and stimulate the body's immune system.  Read More

    Spider Silk Could Be Used to Create Artificial Skin to Help Heal Wounds

    Researchers from Sweden and India have come up with yet another novel use for spider silk’s unusual mix of strength and elasticity: Creating artificial skin and wound dressings for helping heal wounds. “We have developed two types of silk-based constructs: Nanofibrous matrices which serve as bioactive wound dressings, and microporous sponges cultured with human skin cells to serve as artificial skin. Read More

  • July 23, 2018

    Diabetes Doubles Risk for Hospital Acquired Foot Ulcers

    Patients with diabetes have at least double the risk for developing hospital-acquired foot ulcers vs. those without diabetes, according to a study published in BMJ Open Diabetes Research & Care. Patients included in the analysis were aged at least 50 years and developed a hospital-acquired foot ulcer at least 48 hours after hospital admission. For all admissions, the analyses included data on diabetes, heel ulcer, length of stay and other covariates. Read More

    Pioneering Bandage Speeds up Wound Healing in People With Diabetes

    A bandage that could speed up the healing process of foot sores among people with diabetes has been developed. The bandage device, created by researchers at Northwestern University in Illinois, uses the body's own healing ability without the use of drugs or other pharmaceutical products. When tested, the treatment was found to heal diabetic wounds 33% faster when compared with regular bandages.  Read More

    Roundtable Discussion: Tailored Approaches to Venous Ulcers

    Experts discuss the EVRA trial and its applicability to practice, diagnosis of venous ulcers, wound care management and interaction with wound care specialists, treatment of concomitant deep and superficial disease and perforators, and future directions. Read More

    Smart Bandage Can Dispense Drugs, While Keeping An Eye On Your Wound

    The next time you cut your finger and need wound care, stitches and a bandage, wouldn’t it be reassuring to know that your wound is being monitored for signs of infection--and if you need antibiotics, they will automatically be dispensed by the bandage itself? Sounds like this is a futuristic concept, but this may soon be how you and your health care provider manage your cut, receiving data in a continuous feedback loop that lowers the chance of a wound infection--not to mention reduces the need to make an office or clinic visit for a wound check. Read More


  • July 17, 2018

    Avoiding Injuries

    Pressure ulcers and the accompanying task of preserving residents' skin integrity are never-ending challenges for long-term care providers. Facilities should consistently use a predictive scale for pressure injuries to identify those at high risk for pressure ulcers, The Society for Post-Acute and Long-Term Care Medicine (AMDA) advises. The organization debuted a set of new pocket guides meant to help with issues such as pressure ulcers in April, along with new “Know-It-All Before You Call” cards that help nursing staff evaluate patients and collect data. Read More

    IASST Researchers Use Smart Bandage for Faster Wound Healing

    A smart bandage material that can heal wounds better and faster and has antimicrobial properties has been fabricated by a team of researchers from the Institute of Advanced Study in Science and Technology (IASST), Guwahati. The bandage is made of cotton patch coated with chitosan-based hydogel that is loaded with curcumin and graphene oxide. The researchers used curcumin as a model drug and the same can be replaced with other antimicrobials. Read More

    Skin and Soft Tissue Infections on the Decline, Yet Still High Among Patients with HIV

    Research published in Clinical Infectious Diseases found that the rate of skin and soft tissue infections (SSTIs) have been on the decline following the previous rise in SSTIs in the early 1990s and 2000s due to methicillin-resistant Staphylococcus aureus (MRSA) infections. Additionally, researchers of the retrospective study saw that HIV-infected patients are more at risk for SSTIs than the general population. “The higher burden of SSTIs among people living with HIV is likely to impact care for these individuals as it adds further complications to an already burdensome disease,clinicians should be aware of the increased potential for skin infections and advise their patients on how to prevent infection.” Read More

    Awareness Week Starts Conversation on Wound Management

    Wound Awareness Week runs from 15-21 July and this year’s theme ‘Let’s Talk About Wounds’ is encouraging people to start a conversation with their health professionals about wound healing and management. As part of the Wound Awareness Week, Wounds Australia are organizing a number of initiatives to help start the conversation. Read More


  • July 9, 2018

    Carbon Fiber Orthoses May Improve Activity Performance After Severe Lower Extremity Trauma

    Researchers compared physical performance between military service members with lower extremity trauma resulting in limb salvage (n = 20) or unilateral transtibial amputation (n = 14) and uninjured actively training service members (n = 123) using four-square step, sit-to-stand 5 times and timed stair ascent tests. Researchers assessed patients in the limb salvage group with and without the use of a carbon fiber orthosis. They used associations between these lower extremity activity measures to determine the interrelationship of activity limitations. Read More

    Greater Concentration on Wound Care Will Save NHS Millions Argues Prof of Vascular Surgery

    It is estimated that annually the NHS treats over two million wounds at a cost of £5.3 billion and with tougher financial constraints being announced every year, there needs to be ongoing research to ensure the lack of finances doesn't affect the quality of wound care available. This was the topic of the opening lecture at the 3rd International Skin Integrity and Tissue Viability Conference hosted by the University of Huddersfield's Institute of Skin Integrity and Infection Prevention (ISIaIP), in conjunction with the Journal of Wound Care. Read More

    No Benefit of Negative Pressure Wound Therapy for Lower Extremity Open Fractures

    Open fractures are usually treated with surgical debridement and fixation, following which patients are often subject to routine local wound care either with standard dressings or NPWT. With the severity of these fractures, reduced quality of life is common and is unknown how different wound management strategies affect recovery. In this multicenter, randomized controlled trial, no differences were found in the mean self-reported disability at 3, 6, 9, or 12 months post between patients randomized to the NPWT or stand wound dressing groups. Read More

    Ankle Salvage Possible After Distal Tibial Nonunion

    Periarticular distal tibial nonunions can be tricky to treat, but Mount Sinai researchers have found that ankle-sparing bone transport can be an effective alternative to bone graft and arthrodesis. Their study, “Ankle Salvage Following Nonunion of Distal Tibia Fractures," was published online in the Foot and Ankle International on June 4, 2018. Ettore Vulcano, M.D., assistant professor of Orthopaedics at the Icahn School of Medicine at Mount Sinai, and his colleagues evaluated radiographic and clinical outcomes of 21 patients who underwent ankle-sparing bone transport for periarticular distal tibial nonunions between January 2006 and July 2016. Read More


  • July 2, 2018

    Researchers Report Biomedical Applications of Cuttlefish Bone

    A group of researchers of Kaunas University of Technology (KTU) has developed several innovative applications of cuttlebone, natural biologically active material possessing bone and wound healing properties. The products include natural bone implants, suppositories for treatment of hemorrhoids and wound gels. By removing protein from the cuttlebone, KTU researchers have reduced the risk of side effects, such as allergic reaction of potential users. Read More

    New Bandage May Help Wounds Heal More Quickly for People with Diabetes

    Getting blisters from breaking in a new pair of shoes isn’t a big deal for many, but a person with diabetes could pay a much bigger price. Something as benign as a blister can easily become infected, eventually requiring surgery or multiple treatments. At its potential worst, an amputation could be required. Researchers at Northwestern University in Illinois have developed a new device that they hope will not only expedite the healing speed of a wound for diabetes patients but also prevent the need for infection-based operations altogether. Read More

    Super Absorbent Wound Dressing Will Swell up to Save Soldiers’ Lives in Combat

    According to the U.S. Army, around 80 to 90 percent of potentially survivable deaths among American soldiers on the battlefield occur as the result of uncontrolled bleeding. With that shocking stat in mind, it’s no surprise to hear that the Army is working on a new kind of wound dressing which could help patch up bleeding wounds — and hopefully save hundreds, or even thousands, of lives in the process. The new polystyrene and rubber wound dressing boasts an amazing amount of absorbency, letting it absorb up to 800 percent of the material’s weight in liquid. Read More

    The Physician’s Role in Providing Individualized Burn Care

    Pain is a complex concept, which presents numerous clinical and ethical complexities for caregivers and patients in burn care settings. Good clinical and ethical decision making in these settings demands attention to topics such as end-of-life practices and how to regard consent, refusal and other expressions of a patient’s autonomy. One famous burn patient’s case has been particularly influential. Read More