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Featured Articles

  • October 22, 2019

    Researchers Discover a New Defensive Mechanism Against Bacterial Wound Infections

    Wound inflammation that results in impaired wound healing can have serious consequences for patients. Researchers from Charité - Universitätsmedizin Berlin have discovered a new defensive mechanism that enables skin to actively kill bacteria. Central to this mechanism is a cellular messenger molecule known as interleukin 6, whose mode of action may be used in the future to prevent wound infections. Results from this research have been published in PNAS. Read More  

    How Do Ketogenic Diets Affect Skin Inflammation?

    Not all fats are equal in how they affect our skin, according to a new study in the Journal of Investigative Dermatology. The investigators found that different ketogenic diets impacted skin inflammation differently in psoriasiform-like skin inflammation in mice. Ketogenic diets heavy in medium-chain triglycerides (MCTs) such as coconut, especially in combination with omega-3 fatty acids from fish oil and plant sources like nuts and seeds, exacerbated psoriasis.  Read More

    Smart Insole Can Double as Lifesaving Technology for Diabetic Patients

    Stevens Institute of Technology has signed an exclusive licensing agreement with Bonbouton, giving the cutting-edge health and technology company the right to use and further develop a graphene sensing system that detects early signs of foot ulcers before they form so people living with diabetes can access preventative healthcare and confidently manage their health. Read More

  • October 15, 2019

    First Application of Genetically Modified, Live-Cell, Pig Skin to a Human Wound

    Burn specialists at Massachusetts General Hospital (MGH) announced today they have successfully used live-cell, genetically engineered pig skin (xenograft) for the temporary closure of a burn wound. Through an FDA-cleared phase one clinical trial led by surgeon Jeremy Goverman, MD, of the MGH Sumner Redstone Burn Service, this procedure marks the first-time pig tissue derived from an animal with gene edits has been transplanted directly onto a human wound. Read More  

    Statins Linked to Higher Risk of Diabetes and Skin Infections

    Statins have been reported to be beneficial for infections such as pneumonia and Staphylococcus aureus bacteraemia. In the case of skin and soft tissue infections however, statin use is ironically associated with an increased risk of developing diabetes, which is a risk factor for such infections.  Read More

    Negative Pressure Wound Therapy May Increase Deep Infection Rate

    Patients managed with negative pressure wound therapy for severe open fracture wounds experienced lower physical quality of life scores and higher odds of developing deep infections that required operative management compared with patients who did not have the therapy, according to results presented at the Orthopaedic Trauma Association Annual Meeting. Read More

  • October 8, 2019

    Better Treatment for Diabetic Foot Ulcers

    People with type 2 diabetes often suffer from poorly-healing infected wounds on their feet. Using existing methods, however, it takes two days to grow a bacterial culture used to identify the pathogens infecting the wound and their antibiotic resistance—and thus to find an effective antibiotic. With the help of a new rapid test developed by Fraunhofer researchers, it will take just one hour to obtain this information in the future. Read More  

    New Biofabrication Method Creates One Scaffold to Guide Regeneration of Multiple Tissues

    Organs, muscles and bones are composed of multiple types of cells and tissues that are carefully organized to carry out a specific function. For example, kidneys are able to filter waste from the blood because of how their specialized cells and tissues are arranged. Disrupting this organization dramatically affects how cells and tissues do their job effectively. Read More

    Reducing Lymphedema Risk with Exercise

    Many breast cancer patients worry about complications of treatment, one of which is lymphedema, or swelling of the arms after surgery or radiation. Exercise has been thought to possibly trigger or make lymphedema worse, so some heath care providers recommend that their patients avoid exercise. However, Dr. Sarah McLaughlin, a Mayo Clinic surgeon, says exercise may help prevent lymphedema and lessen its symptoms.  Read More

  • October 1, 2019

    Using Unconventional Materials, like Ice and Eggshells, as Scaffolds to Grow Tissues

    Researchers explore recent efforts to use everyday materials like ice, paper, and spinach as tissue scaffolds. These unconventional materials, they argue, are more functional, more sustainable, and less expensive, as well as being available around the globe and applicable to many areas of biomedical research. Read More  

    Patients' Avatars Being Used to Test Cystic Fibrosis Drugs

    UNSW researchers are leading a revolutionary approach to managing treatment of cystic fibrosis using patients' derived lung and gut mini-organs or avatars to test how they will respond to the latest drugs. Read More

    Novel Strategy Using Microrna Biomarkers Can Distinguish Melanomas from Nevi

    Melanoma is the least common but one of the most deadly skin cancers. It accounts for only about one percent of all cases globally, but the majority of skin cancer deaths. Accurate, timely and reliable diagnosis of cutaneous melanoma remains a significant challenge in dermatopathology. Investigators report in the Journal of Investigative Dermatology, published by Elsevier, on a novel strategy for using microRNA (miRNA) biomarkers to detect melanoma cells in skin tumors even when the tumor contains predominantly benign cells.  Read More

  • September 24, 2019

    Platelet-Rich Plasma May Facilitate Ulcer Healing

    Platelet-rich plasma, or PRP, appears to yield healing in ulcers as it changes the matrix metalloproteinase and cytokine expression shortly after topical application, according to researchers. “These articles demonstrate that topical activated PRP or autologous leukocyte- and platelet-rich fibrin applied once to twice a week for 3 to 6 weeks improves wound healing and support a standardized treatment regimen for PRP in chronic ulcers,” Michael J. Hesseler, MD, of the department of dermatology at University of Michigan, and colleagues wrote.Read More  

    Once Considered Rare, an Itchy Dermatologic Skin Disorder Is More Common Than Thought  

    Johns Hopkins researchers report that prurigo nodularis (PN), a skin disease characterized by severely itchy, firm bumps on the skin, may be associated with other inflammatory skin disorders as well as systemic and mental health disorders. Compared with other skin diseases, however, not much is known about PN. While symptoms of PN can be managed, no cures exist. Researchers were looking to determine associated conditions that are more common in patients with PN. Read More

    Pressure Ulcer Prevention - Risk Assessment

    Preventing pressure ulcer formation begins with a thorough examination of the patient in order to identify the risk factors for the individual, which then allows the clinician to implement effective prevention strategies. The adage “an ounce of prevention is worth a pound of cure” is most appropriate when applied to pressure injuries/ulcers. Studies have shown that pressure ulcers (PU) increase the hospital length of stay approximately 8 days.[1] Approximately 2.5 million persons in the US are affected by PUs each year, with the following cost statistics: “Pressure ulcers cost $9.1-$11.6 billion per year in the US.  Read More

    Using Unconventional Materials, like Ice and Eggshells, as Scaffolds to Grow Tissues

    As the global demand for tissue and organ transplants significantly outstrips supply, tissue engineering might provide a potential solution. But one of the significant challenges in tissue engineering is growing tissue in 3D, and the scaffolds used to position cells to develop tissue-specific functions are often challenging or prohibitively expensive to develop. Read More

  • September 17, 2019

    Failed Cancer Drug Looks Promising for Scleroderma and Other Fibrotic Conditions 

    Sixteen years ago, a research group at Mayo Medical School published results showing that a protein called TRAIL can kill cells that cause liver fibrosis but no one seemed to follow up on these findings. Now, researchers at Johns Hopkins Medicine have improved on this protein and shown that it selectively kills cells that cause the hardening of skin associated with scleroderma, effectively reversing the condition in mice genetically engineered to mimic the disease. A report on these results was published earlier this year in Nature Communications.  Read More  

    Novel Approach Leads to Potential Sepsis Prevention in Burn Patients  

    Immediately following severe burns, bacteria reach the wound from different sources, including the patient's skin, gastrointestinal tract, respiratory tracts and health care-related human contact. Within the wound, bacteria multiply, establish an infection and move from the infected burn wound into the bloodstream, causing serious complications like sepsis, multiple-organ failure and death. Read More

    How Lymphoma Cells Metastasize to the Brain

    Lymphomas in the central nervous system are rare but dangerous. Scientists at the German Cancer Research Center (DKFZ) have now discovered which molecular mechanism leads to lymphomas forming metastases in the central nervous system. Using a mouse model, the researchers showed that chronic inflammatory processes in aging brains lead to lymphoma cells that have entered the brain tissue being retained instead of being released directly back into the blood. They also identified key molecules of this mechanism in tissue samples from patients with lymphomas of the central nervous system.  Read More

    AI-Based Algorithm May Predict Nonmelanoma Skin Cancer in High-Risk Patients

    A nonmelanoma skin cancer risk prediction model using readily available information in the electronic medical records system and a deep learning approach appeared to demonstrate robust discrimination, according to findings published in JAMA Dermatology. “This machine learning-based prediction tool may facilitate determination of which patients are likely to develop [nonmelanoma skin cancer]. Read More