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Featured Articles

  • November 7, 2018

    Efforts to Prevent Pressure Ulcers in Hospitals May Not be Making Headway on the Worst Kind

    In a new paper in the November issue of Health Affairs, the research team from the University of Michigan recommends better ways of tracking HAPUs for value-based purchasing policies. The program should use the same approach hospitals already use to track infections that patients develop during their stay, and adjust rates and penalties based on patients' underlying risk. Better data will mean more valid penalties for HAPUs, which affect 2.5 million patients in the U.S. alone, lead to the deaths of about 60,000 of them a year, and cost about $10 billion to treat. Read More

    Machine Learning Yields Fresh Insights Into Pressure Injury Risks

    Big data and machine learning helped develop a model for predicting risk for pressure injuries in critical care patients, according to new research published in the November issue of American Journal of Critical Care (AJCC). In “Predicting Pressure Injury in Critical Care Patients: A Machine-Learning Model,” the research team examined five years of data on patients admitted to the adult surgical or surgical cardiovascular intensive care units at the University of Utah Hospital in Salt Lake City. Among the sample of 6,376 patients, hospital-acquired pressure injuries of stage 1 or greater developed in 516 patients, and injuries of stage 2 or greater developed in 257 patients. Read More

    Risk Factors of Intraoperative Pressure Injuries in Patients Undergoing Digestive Surgery: A Retrospective Study

    Basic information and the results of 3S intraoperative risk assessment scale of pressure injury were obtained from the information system. And the patients with intraoperative blanchable erythema or pressure injuries were followed up for 72 hours by the information system. The clinical data were collected to analyze risk factors of intraoperative blanchable erythema and pressure injuries by univariate analysis and logistic regression analysis. STROBE checklist for cohort studies was applied in the preparation of the paper. Of 5136 surgical cases, 134 (2.61%) had blanchable erythema, 37 (0.72%) had intraoperative pressure injuries, and 8 (0.16%) had pressure injuries at 72h follow-up. Preoperative skin under compression, preoperative physical activity, surgical position, and extra intraoperative pressure were considered independent risk factors of intraoperative pressure injuries.  Read More

    Evaluation of Fluorescence Biomodulation in the Real-Life Management of Chronic Wounds: the EUREKA Trial.

    Fluorescence biomodulation (FB), a form of photobiomodulation (PBM) that is also known as low energy level light (LELL), has become an increasingly used clinical tool to induce wound healing in wounds that remain recalcitrant to treatment. Read More

  • October 30, 2018

    The Necessity of the Simple Tests for Diabetic Peripheral Neuropathy in Type 2 Diabetes Mellitus Patients without Neuropathic Symptoms in Clinical Practice

    Diabetic peripheral polyneuropathy (DPNP) is the most common microvascular complication and an amputation risk factor in patients with diabetes. Therefore, early recognition and appropriate management of DPNP are important. Unfortunately, methods for DPNP detection are underutilized in primary-care practice and DPNP is underdiagnosed. To confirm the diagnosis, a nerve-conduction study or skin biopsy is required. However, these procedures are invasive and may be unsuitable for use in clinical practice. The identification of potential patients with DPNP, particularly by non-specialists, requires easily applicable and clinically reliable screening and diagnostic methods.  Read More

    Condom Catheter Induced Penile Skin Erosion

    Condom catheters are widely used in the management of male urinary incontinence, bedridden patient and geriatric population. They are considered to be safe, however, they are associated with complications in care of an incorrect use. In our hospital setup a 73-year-old male bedridden patient attended the surgical opd with complain of penile skin erosion following condom catheter application for 4 days for which dressing was done to remove the slough for 2 days then circumcision was done. Henceforth, although a less known complications are associated with the condom catheter but if not attended promptly can lead to a grave condition like penile gangrene, necrosis, death.  Read More

    Novel Combination Therapy Promotes Wound Healing

    By incorporating a gene-suppressing drug into an over-the-counter gel, researchers at Albert Einstein College of Medicine and their colleagues cut healing time by half and significantly improved healing outcomes compared to control treatments. Results from the combination therapy, which was tested in mice, were published online today in Advances in Wound Care. "Not only did wound healing occur more rapidly and completely, but actual regeneration occurred, with hair follicles and the skin's supportive collagen network restored in wounded skin—clinically important improvements that are unprecedented in wound care," says senior author David J. Sharp, Ph.D, professor of physiology & biophysics at Einstein. "We foresee this therapy having broad application for all sorts of wounds, from playground cuts to battlefield injuries to chronic wounds.  Read More

    Study Identifies Gene That Makes Gentle Touch Feel Painful After Injury

    Ever wonder why things that normally feel gentle, like putting on soft shirts, are painful after a sunburn? In a study of four patients with a rare genetic disorder, NIH researchers found that PIEZO2, a gene previously shown to control our sense of our bodies in space and gentle touch, may also be responsible for tactile allodynia: the skin's reaction to injury that makes normally gentle touches feel painful. This and a second NIH-funded study, both published in Science Translational Medicine, used mice to show how the gene may play an essential role in the nervous system's reaction to injury and inflammation, making PIEZO2 a target for developing precise treatments for relieving the pain caused by cuts, burns, and other skin injuries. Read More

  • October 22, 2018

    Thermal Imaging Improves Diabetes-Related Foot Ulcer Assessment

    Thermal imaging can better predict a diabetes related foot ulcer's size and the healing trajectory than conventional methods, Melbourne-led research has found. It could also possibly save money through better targeted treatment. The study, which was the first of its kind, was a collaboration between RMIT University, the University of Melbourne and Austin Health. It used thermal imaging to quantify the size and predict the healing status of recently developed ulcers. Read More

    How Fatal Biofilms Form

    By severely curtailing the effects of antibiotics, the formation of organized communities of bacterial cells known as biofilms can be deadly during surgeries and in urinary tract infections. Researchers have just come a lot closer to understanding how these biofilms develop, and potentially how to stop them. Biofilms form when bacterial cells gather and develop structures that bond them in a gooey substance. This glue can protect the cells from the outside world and allow them to form complex quasi-organisms. Biofilms can be found almost everywhere, including unwashed shower stalls or the surfaces of lakes. Because the protective shell can keep out potential treatments, biofilms are at their most dangerous when they invade human cells or form on sutures and catheters used in surgeries. Read More

    Combined Therapy in the Treatment of Mixed Etiology Leg Ulcer

    The most frequent causes of leg ulcers are chronic venous disease (CVD) related mainly to venous hypertension and peripheral arterial disease (PAD) related to disseminated atheromatous lesions in lower limb arteries. In 15%–21% of patients, ulcers of mixed venous-arterial etiology occur, which are usually more resistant for conservative therapy (compression therapy, pharmacotherapy, wearing elastic stockings, leg elevation and massage, change of lifestyle, and regular physical exercises).  Read More

    Advancements in Regenerative Strategies Through the Continuum of Burn Care

    Currently, multiple strategies exist for the management of burn wounds depending on both the depth and extent of the burn. Burn wound care strategies aim to modulate the inflammatory response, accelerate re-epithelialization, and improve overall wound healing. Furthermore, combinatorial approaches that incorporate cellular-based therapies, pharmacological agents, and biomaterials are utilized to minimize infection and serve as burn wound coverage adjuncts with the goal of restoration of skin function (i.e., barrier, range of motion, sensation, hair and sweat generation, and pigmentation). This review focuses on how therapies for burn injuries are currently being developed to address the array of issues that occur throughout the continuum of burn care. Read More

  • October 18, 2018

    Acting Fast Is Key with Necrotizing Fasciitis

    Necrotizing fasciitis is a bacterial infection of the tissue under the skin that surrounds muscles, nerves, fat, and blood vessels. The bacteria most commonly get into the body through a break in the skin. Once in the body, the bacteria spread quickly and destroy the tissue they infect. Media reports often call them “flesh eating bacteria.” Unfortunately, necrotizing fasciitis can result in a loss of limbs and even death. Accurate diagnosis, rapid antibiotic treatment, and prompt surgery are important to stopping this infection. Read More

    UTA Researchers Patent Technology for Smart Seat Cushion, Adaptable Prosthetics

    The University of Texas at Arlington has patented a smart seat cushion that uses changes in air pressure to redistribute body weight and help prevent the painful ulcers caused by sitting for long periods of time in a wheelchair. The same technology can be used to create prosthetic liners that adapt their shape to accommodate changes in body volume during the day and maintain a comfortable fit for the prosthesis. Poor prosthetic fit can cause skin damage and create sores in the residual limb of the wearer. Read More

    Photoactive Bacteria Bait May Help in Fight Against MRSA Infections

    Purdue University researchers are testing whether a simple light-emitting diode array that is safe to use on human skin can be used to inactivate methicillin-resistant Staphylococcus aureus, or MRSA, one of six 'high priority' pathogens that the World Health Organization has identified as an imminent threat to public health. Here the light shines above a 96-well plate in a bio-safety hood. Read More

    Diabetic Foot Disease

    Diabetic foot disease is a severe complication of neuropathy and/or peripheral vascular disease and can lead to chronic infection, foot ulcers, gangrene, and lower-limb amputation. Every year, about 1% to 4% of people with diabetes develop a new foot ulcer. A foot ulcer is the initial event in more than 85% of amputations performed on those with diabetes. Although the rate of foot and leg amputation has greatly declined over the past 2 decades, increasing awareness is essential because diabetes is the leading cause of lower-limb amputations in the United States. Read More

  • October 10, 2018

    Calcipotriol Ointment Seen to Improve Wound Healing in RDEB Patient, Study Finds

    A low dose of calcipotriol, which is already approved for the treatment of psoriasis, may improve healing and prevent wound infections in patients with recessive dystrophic epidermolysis bullosa (RDEB), a study showed. Read More

    Ginsenoside Rb1 Enhances Keratinocyte Migration by a Sphingosine-1-Phosphate-Dependent Mechanism

    The cutaneous wound healing process is tightly regulated by a range of cellular responses, including migration. Sphingosine-1-phosphate (S1P) is a signaling lipid produced in keratinocytes (KC) and it is known to stimulate skin wound repair through increased KC migration. Of the multifunctional triterpene ginsenosides, Rb1 enhances cutaneous wound healing process by increasing KC migration, but cellular mechanisms responsible for the Rb1-mediated increase in KC migration are largely unknown. Therefore, we hypothesized that, and assessed whether, Rb1 could stimulate KC migration through S1P-dependent mechanisms. Rb1 significantly increases S1P production by regulating the activity of metabolic conversion enzymes associated with S1P generation and degradation, sphingosine kinase 1 (SPHK1) and S1P lyase, respectively, in parallel with enhanced KC migration. Read More

    The Role of Saline Irrigation Prior to Wound Closure in the Reduction of Surgical Site Infection: Protocol for a Systematic Review and Meta-Analysis

    Surgical site infection describes an infectious complication of surgical wounds. This single complication is thought to occur in close to 20% of surgical cases. This complication has been described in all kinds of surgical procedure including minimally invasive procedures. Wound irrigation is frequently used as a means of reducing surgical site infection. However, there is lack of solid evidence to support routine wound irrigation. The aim of this review is to provide evidence for the efficacy of routine wound irrigation with normal saline in preventing surgical site infection. The rate of surgical site infection in cases with and without wound irrigation will be analyzed. Read More

    Effect of Perioperative Oral Management on the Prevention of Surgical Site Infection After Colorectal Cancer Surgery

    Surgical site infection (SSI) is 1 of the frequent postoperative complications after colorectal cancer surgery. Oral health care has been reported to reduce the risk of SSI or postoperative pneumonia in oral, esophageal, and lung cancer surgeries. The purpose of the study was to investigate the preventive effect of perioperative oral management on the development of SSI after a major colorectal cancer surgery. Read More

  • October 2, 2018

    Hospital Privacy Curtains Harbor Infectious Bacteria

    Patient privacy curtains in hospitals became increasingly contaminated with pathogens and most tested positive for MRSA after 21 days of being hung, according to findings published in the American Journal of Infection Control. "Since hospital patient privacy curtains can harbor bacteria, are high-touch surfaces and are cleaned infrequently, they may be involved in pathogen transmission,” Kevin Shek, BSc, from the University of Manitoba, Canada, and colleagues wrote. Read More

    Atherectomy Successful in PAD; Patency Rates Similar Among Device Types

    Patients with occlusive lower extremity peripheral artery disease treated with atherectomy devices had over 96% procedural success, according to data presented at TCT 2018. When the researchers compared results by atherectomy device type, excisional atherectomy was associated with higher rates of vessel dissection and perforation and lower amputation rates compared with laser or orbital atherectomy, although long-term vessel patency was similar in all groups. Read More

    Three Factors that Predict Life-Threatening Respiratory Disease in Burn Patients

    For the first time, researchers have devised a model to predict burn patients who are most likely to develop life-threatening acute respiratory distress syndrome (ARDS). The prediction model includes three factors: the extent of the patient's inhalation injury, the percentage of the patient's body that was burned and whether the patient had high levels of a blood clotting protein called von Willebrand factor. Read More

    Use of Continuing Education to Increase Nurses' Knowledge of Chronic Wound Care Management

    Providing effective management of chronic wounds can be a major challenge for nurses practicing in health care systems. As the older adult population continues to increase, the prevalence of chronic health-related diseases that can lead to chronic wounds has also increased. Nurses have reported a lack of preparation in the management of chronic wounds. Read More