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Featured Articles

  • May 8, 2019

    3M Rolls Out Its Biggest Deal: $6.7B to Buy Wound-Care Company

    3M Co.'s $6.7 billion purchase of wound-care company Acelity Inc. will be the biggest acquisition in its history. The Maplewood-based 3M, which makes everything from Post-it notes to safety equipment and optical films, said Thursday it is buying San Antonio-based Acelity and its KCI subsidiaries from investment funds Apax Partners, Canada Pension Plan Investment Board and the Public Sector Pension Investment Board. The deal includes the assumption of $2.4 billion of Acelity debt. Read More

    Researchers Pinpoint Microbial Strains That Delay Healing in Diabetic Foot Ulcers

    Researchers at the University of Wisconsin-Madison have identified specific strains of microbiota in patients with slow-healing diabetic foot ulcers, indicating the microbiomes of foot ulcers could predict clinical outcomes and responses to therapeutic interventions, according to findings published in Cell Host and Microbe. “Our study has shown for the first time that differences at the strain-level within bacterial species can be associated with different outcomes,” Lindsay Kalan, PhD, assistant professor of medical microbiology and immunology at the School of Medicine and Public Health at the University of Wisconsin-Madison, told Endocrine Today. Read More

    Nanofiber-Hydrogel Composite Allows Soft Tissue to Regenerate

    A team of researchers at Johns Hopkins School of Medicine has developed a gel that, when injected into test animals, allowed new soft tissue to grow—replacing lost tissue. In their paper published in the journal Science Translational Medicine, the group describes their work developing the gel and how well it worked in test rats and rabbits. When a person loses a chunk of soft tissue due to an accident, infection or surgical procedure, surgeons have very few options available to induce the body to regenerate the missing tissue, leaving patients with disfiguring reminders of their loss. In this new effort, the researchers have developed a new gel that shows promise as a soft-tissue regenerative tool. Read More

    Atopic Dermatitis Associated with Extracutaneous Infections

    Extracutaneous infections, particularly ear infections, strep throat and urinary tract infections, have an increased likelihood in patients with atopic dermatitis, according to a literature review. Linda Serrano, MD, and colleagues from Northwestern University Feinberg School of Medicine, reviewed all published observational studies that included controls and evaluated the relationship between atopic dermatitis and bacterial infections. Seven studies, published between 1994 and 2018, were included in the analysis.The researchers identified a higher prevalence of numerous extracutaneous infections across multiple studies. Read More

  • May 2, 2019

    Porcupine Barbs For Better Wound Healing

    At first, the idea of using porcupine quills to patch up wounds sounds torturous. But, taking inspiration from the spiky rodent, researchers have begun to work on a new type of surgical staple that may be less damaging — and less painful — than current staples. Worldwide, surgeons perform more than 4 million operations annually, usually using sutures and staples to close wounds. Yet these traditional tools designed to aid healing can create their own problems. "We've been using sutures and staples for decades, and they've been incredibly useful," says Jeff Karp, a bioengineer at Brigham and Women's Hospital in Boston and professor of medicine at Harvard Medical School. "But there are challenges in terms of placing them for minimally invasive procedures." Read More

    3D Printing Grows Up, Heals Wounds by Printing Skin

    Scientists have created a mobile bioprinter that when filled with a patient's cells, prints skin directly into a wound. We've been writing about 3D printing for what seems like forever. From its sustainable benefits to its ability to spit out $4000 tiny homes and grand architectural statements alike. Not to mention entire colonies on Mars. But now additive manufacturing has crept into a new realm with the first-ever mobile bioprinter; it doesn't layer plastic into design shapes, but rather, prints skin onto wounds. It's not the first time that 3D printing has been used in medicine – they've used it to create organs and vessels and limbs. But the practicality and efficacy of a mobile skin printer surely seems like it could come in handy. Read More

    Suture Spacing Yields Similar Cosmetic Outcomes During Linear Wound Closures

    Researchers reported no statistically significant difference in wound cosmesis or total complications between running cutaneous sutures spaced 2 mm or 5 mm apart among patients who underwent Mohs procedures or surgical excision on the head or neck. “There appears to be significant variation among surgeons regarding the spacing between sutures,” Lindsay R. Sklar, MD, of the department of dermatology at the University of California, Davis, School of Medicine, and colleagues wrote. “Some prefer closely spaced sutures, believing they result in better wound edge apposition and eversion and less potential edge misalignment. Read More

    Microbiomes of Diabetic Foot Ulcers are Associated With Clinical Outcomes

    New research suggests that the microbial communities associated with chronic wounds common in diabetic patients affect whether those wounds heal or lead to amputations. Work led by University of Wisconsin School of Medicine and Public Health Professor of Medical Microbiology and Immunology Lindsay Kalan and her colleagues at the University of Pennsylvania found that particular strains of the common pathogen Staphylococcus aureus exclusively infected diabetic foot ulcers that never healed, indicating these strains may delay healing. Read More

  • April 25, 2019

    Photobiomodulation Therapy for Wound Care: A Potent, Noninvasive, Photoceutical Approach

    The use of light therapy dates back to ancient civilizations, going as far back as the ancient Egyptians and Indians, who used sunlight (heliotherapy) for healing and promoting health. The therapeutic use of light energy was more fully appreciated in the late 19th century when a Danish physician-scientist, Niels Ryberg Finsen, demonstrated the benefits of red and blue light in the treatment of lupus vulgaris and was recognized with the 1903 Nobel Prize in Medicine and Physiology. In 1960, the L.A.S.E.R. (Light Amplification by Stimulated Emission of Radiation) by Theodore Maiman was invented, based on theoretical work by Albert Einstein in 1917. Read More

    3D Images, Algorithms are Key in Potential New Tool for Measuring Bedsores in Spinal Cord Injury

    Investigators at the James A. Haley Veterans’ Hospital in Tampa, Florida, are testing an innovative computer-based system designed to more accurately measure bedsores, also known as pressure ulcers. Accurate measurement of the wound, followed by optimal treatment, is key to preventing it from worsening. People with spinal cord injuries are at high risk for developing pressure ulcers due to immobility, a lack of sensation, moisture, and other risk factors. Pressure ulcers are painful injuries to the skin and underlying tissue resulting from prolonged pressure on the skin. They most often develop on skin that covers bony areas of the body, such as the heels, ankles, hips, and tailbone, and they can appear due to a lack of blood flow. They can also lead to the premature death of cells in living tissue. Read More

    Welding With Stem Cells for Next-Generation Surgical Glues

    Scientists at the University of Bristol have invented a new technology that could lead to the development of a new generation of smart surgical glues and dressings for chronic wounds. The new method, pioneered by Dr Adam Perriman and colleagues, involves re-engineering the membranes of stem cells to effectively "weld" the cells together. Cell membrane re-engineering is emerging as a powerful tool for the development of next generation cell therapies, as it allows scientists to provide additional functions in the therapeutic cells, such as homing, adhesion or hypoxia (low oxygen) resistance. At the moment, there are few examples where the cell membrane is re-engineered to display active enzymes that drive extracellular matrix production, which is an essential process in wound healing. Read More

    Wearable Sensors Simic Skin to Help With Wound Healing Process

    Researchers at Binghamton University, State University of New York, have developed skin-inspired electronics to conform to the skin, allowing for long-term, high-performance, real-time wound monitoring in users."We eventually hope that these sensors and engineering accomplishments can help advance healthcare applications and provide a better quantitative understanding in disease progression, wound care, general health, fitness monitoring and more," said Matthew Brown, a PhD student at Binghamton University. Biosensors are analytical devices that combine a biological component with a physiochemical detector to observe and analyze a chemical substance and its reaction in the body. Conventional biosensor technology, while a great advancement in the medical field, still has limitations to overcome and improvements to be made to enhance their functionality. Read More

  • April 18, 2019

    Surgical Site Infection Rates Differ By Gender for Certain Procedures

    Men and women are at differing risks of developing surgical site infections depending on the type of operation they undergo, according to new research being presented at this year's European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Amsterdam, Netherlands (13-16 April). The findings, generated from national surveillance data and involving over a million operations, indicate that women may be at greater risk than men for contracting surgical site infections following certain surgeries. Read More

    What Is Regenerative Medicine and How can It promote Wound Healing?

    When traditional treatments fail to heal wounds, many doctors look to modern alternatives to help patients recover. Regenerative medicine is one of the most recent developments to become a worthy treatment alternative.The National Institutes of Health defines regenerative medicine as the process of creating living, functional tissues to repair or replace lost tissue or organ function. Through regeneration, replacement and rejuvenation, regenerative-medicine techniques work with the body’s natural wound-healing processes to promote recovery.Regenerative medicine allows doctors to repair and restore damaged or nonfunctioning tissue cells. What can regenerative medicine do for wound healing? When wounds damage tissues, regenerative medicine can replace the damaged cells or restore them to proper health. This promotes wound healing in various cases. Read More

    WOC Nurse Week 2019

    Not all superheroes wear capes! During Wound, Ostomy and Continence (WOC) Nurse Week, April 14-20, 2019, the WOCN® Society is celebrating and empowering WOC nurses to discover the superhero that lives within them. As educators, researchers, leaders, experts and caregivers, each WOC nurse has a unique set of skills that allow them to bring unparalleled quality and value to the lives of individuals who suffer from non-healing wounds, ostomies, and urinary and fecal incontinence.   Read More

    Electrifying Wound Care: Better Bandages to Destroy Bacteria

    Bandages infused with electricity can help heal wounds faster than typical bandages or antibiotics—but for years, researchers have not really understood why. A recent study by a team at The Ohio State University is offering new clues about the science behind those bandages, and researchers say the findings could help lead to better wound treatment.The bandages belong to a class of therapies called electroceuticals, which are devices that use electrical impulses to treat medical issues such as wounds. The study, published online recently in the journal Scientific Reports by a research team at The Ohio State University, is the first of its kind to look at the ways electroceutical bandages kill bacteria around a wound, allowing wounds to heal faster. Electroceutical bandages have been used to treat wounds since at least 2013. Read More

  • April 11, 2019

    Skin Tissue Engineering: Wound Healing Based on Stem-Cell-Based Therapeutic Strategies

    Normal wound healing is a dynamic and complex multiple phase process involving coordinated interactions between growth factors, cytokines, chemokines, and various cells. Any failure in these phases may lead wounds to become chronic and have abnormal scar formation. Chronic wounds affect patients’ quality of life, since they require repetitive treatments and incur considerable medical costs. Thus, much effort has been focused on developing novel therapeutic approaches for wound treatment. Stem-cell-based therapeutic strategies have been proposed to treat these wounds. They have shown considerable potential for improving the rate and quality of wound healing and regenerating the skin. However, there are many challenges for using stem cells in skin regeneration. In this review, we present some sets of the data published on using embryonic stem cells, induced pluripotent stem cells, and adult stem cells in healing wounds. Additionally, we will discuss the different angles whereby these cells can contribute to their unique features and show the current drawbacks. Read More

    Sweat Gland Organoids Contribute to Cutaneous Wound Healing and Sweat Gland Regeneration

    Sweat glands perform a vital thermoregulatory function in mammals. Like other skin components, they originate from epidermal progenitors. However, they have low regenerative potential in response to injury. We have established a sweat gland culture and expansion method using 3D organoids cultures. The epithelial cells derived from sweat glands in dermis of adult mouse paw pads were embedded into Matrigel and formed sweat gland organoids (SGOs). These organoids maintained remarkable stem cell features and demonstrated differentiation capacity to give rise to either sweat gland cells (SGCs) or epidermal cells. Moreover, the bipotent SGO-derived cells could be induced into stratified epidermis structures at the air−liquid interface culture in a medium tailored for skin epidermal cells in vitro.  Read More

    Biomedical Applications of Isotope-Dilution Liquid Chromatography

    Isotope dilution is used to determine the quantity of a chemical substance in a sample. In this method, isotopically enriched material is added to a sample which leads to a "dilution" of the standard. Random sampling is then performed to give the ratio of the standard and sample, which can then be used to infer the quantity of material within the sample. Isotope-Dilution Liquid Chromatography is a potent method to determine carbohydrates and sugar levels in alcohol. Mono-and disaccharides can be simultaneously separated and identified with a detection limit of 50 pmol. This method allows the detection of glucose at low isotopic dilution levels ranging from 0.1–1%, while sorbitol can be detected at a labeled/unlabelled ratio of 1:1. These can be detected in samples such as blood serum or amniotic fluid. This has also been used in clinical investigations to determine the concentration of sorbitol in amniotic fluid and in children that suffer from glycogen storage disease type I.   Read More

    Restrict Movement, Door Openings to Reduce SSI Risk During Surgery

    Findings from a multicenter, observational study conducted in France revealed an association between the movements of staff in the operating room, or OR, during surgery and the risk for surgical site infections. “We aimed to objectively describe and assess staff behaviors in the OR and their variability by recording staff movements using a motion tracking system and door-openings detection system,” Gabriel Birgand, PhD, a researcher affiliated with several institutions in Paris, and colleagues wrote. “We also assessed correlations between movements of the OR personnel and the [surgical site infection (SSI)] risk, as approximated by surrogates of the exogenous infectious risk, in a panel of ORs from two clean surgical specialties.” Read More

  • April 4, 2019

    Bacteria Partners With Virus to Cause Chronic Wounds

    A common bacterial pathogen called Pseudomonas aeruginosa produces a virus that substantially increases the pathogen's ability to infect us, according to a study by investigators at the Stanford University School of Medicine. P. aeruginosa weaponizes its resident virus to exploit the immune system's distinct responses to bacterial versus viral infections. This marks the first time a bacteria-infecting virus, otherwise known as a bacteriophage or just phage, has been observed inducing the immune system to mount an antiviral response and, in doing so, causing it to ignore the bacterial infection. When the scientists generated a vaccine directed at the virus, they showed that it dramatically lowered the bacteria's ability to infect wounds in mice. Read More

    New Therapeutic Approach for Severe Skin Disease

    In the context of a project funded by the Austrian Science Fund FWF, the microbiologist Franz Radner was able to identify an important mechanism of skin metabolism and develop new treatment options for the skin disease ichthyosis. The therapy could also be effective against ageing of the skin. Named after the Greek word for fish, ichthyosis is a rare genetic disease which results in the skin becoming very dry and scaly. There are mild types that do not prevent patients from leading a normal life, but there are also severe types that can be fatal. The condition cannot be cured, but the symptoms can be alleviated with baths and ointments. Franz Radner, a researcher from Graz, was now able for the first time to explore in greater detail how a genetic defect leads to the disease.  Read More

    New Material Will Allow Abandoning Bone Marrow Transplantation

    Scientists from the National University of Science and Technology "MISIS" developed nanomaterial, which will be able to restore the internal structure of bones damaged due to osteoporosis and osteomyelitis. A special bioactive coating of the material helped to increase the rate of division of bone cells by three times. In the future, it can allow to abandon bone marrow transplantation and patients will no longer need to wait for suitable donor material. An article about the development was published in Applied Surface Science. Such diseases as osteoporosis and osteomyelitis cause irreversible degenerative changes in the bone structure. Such diseases require serious complex treatment and surgery and transplantation of the destroyed bone marrow in severe stages.   Read More

    Outbreaks of ‘Medieval’ Diseases Are Becoming More Common in Cities

    In recent months, hepatitis A, Shigella bacteria, and typhus outbreaks have all been reported in cities across the country. Yes, you read all of that correctly. Recent cases of these rare conditions have been cropping up in particularly vulnerable communities in large urban areas. These diseases have especially been on the rise in homeless communities, where lack of medical care and unhygienic conditions have served as a breeding ground for so-called “medieval” diseases — diseases that typically don’t pose a threat to the general American population in the 21st century. Read More