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In situ damage to skin-derived mesenchymal stem cells during neoadjuvant or adjuvant radiotherapy appeared to have a significant effect on the pathogenesis of slow or nonhealing radiation wounds, according to study findings published in Stem Cells Translational Medicine. “Although effective in the treatment of solid tumors, radiotherapy produces a number of off-target effects in the overlying skin,” Alex K. Wong, MD, reconstructive surgeon in the division of plastic and reconstructive surgery at Keck School of Medicine of USC, and colleagues wrote. “These changes result in skin that responds poorly to wounding by trauma or surgery, predisposing to the development of chronic wounds.” Read More
Researcher Abhishek Gupta, of the University of Wolverhampton's School of Pharmacy, developed the new innovative dressings. He said they would provide an alternative to conventional gauze, which could be particularly beneficial for immunocompromized patients such as HIV patients, diabetics and the elderly. They can be used for dry or exudative wounds as they are capable of creating a moist microclimate at the wound site which facilitates healing. Read More
Dupilumab showed consistent and sustained efficacy in an open-label extension study in adults previously enrolled in 12 parent studies assessing dupilumab in moderate to severe atopic dermatitis. “More than half of patients did not require additional treatment for [atopic dermatitis] during the treatment period,” Mette Deleuran, MD, DMSc, of Aarhus University Hospital in Denmark, and colleagues wrote. “This, combined with the relatively small numbers of patients requiring systemic rescue therapy, supports that dupilumab monotherapy or concomitant with topical [atopic dermatitis] medications provides long-term disease control in moderate to severe [atopic dermatitis] patients.” Read More
Researchers at Karolinska Institutet in Sweden have discovered a new sensory organ that is able to detect painful mechanical damage, such as pricks and impacts. The discovery is being published in the journal Science. Pain causes suffering and results in substantial costs for society. Almost one person in every five experiences constant pain and there is a considerable need to find new painkilling drugs. However, sensitivity to pain is also required for survival and it has a protective function. Read More