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Fatty liver disease is often associated with alcoholism, but more than a third of Americans have fatty livers despite moderate or absent alcohol consumption. They suffer from non-alcoholic fatty liver disease, a condition that can lead to cirrhosis, liver cancer and liver failure. Many patients require liver transplants to beat the disorder. Now researchers led by Jouni Uitto, MD, PhD, Professor of Dermatology and Cutaneous Biology at Thomas Jefferson University report mutations in a gene called ABHD5 involved in non-alcoholic fatty liver disease. The finding provides a genetic basis for the condition. Read More
The cell polarity protein Par3 controls mechanic changes in the skin and plays an important role in cell division. Malfunction can lead to DNA damages. The balance of the system is of great importance: while too much differentiation leads to loss of stem cells and therefore premature aging, too many cell divisions can be a cause of skin cancer. The new study by a team around Sandra Iden about how polarity regulators control cellular mechanics in the skin was now published in Nature Communications. Read More
Some medical topics are not for the faint of heart or those with a weaker stomach. One obvious example is that of chronic wounds and their care. As a specialist in foot and ankle medicine, I find this a fascinating topic which occupies a fair amount of my attention. Although not everyone’s cup of tea, wound care is challenging. An extremely common concern, these non-healing sores (technically known as ulcers), are not only a common problem but often very difficult to resolve. Numerous physicians, in a variety of specialties, encounter them in the course of their work. Thus, some healthcare providers practice some degree of wound care. Read More
Dermatologists who think diet and food don’t matter in atopic dermatitis should think again, according to Peter A. Lio, M.D., clinical assistant professor of dermatology and pediatrics at Northwestern University’s Feinberg School of Medicine in Chicago. “Food and diet matter, if for no other reason than the fact that our patients really want to know about it and discuss it,” Dr. Lio says. “There is no doubt that true food allergy is a significant problem for patients with atopic dermatitis, affecting some one-third of patients with moderate-to-severe atopic dermatitis. Read More