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Featured Articles

March 22, 2019

1 in 10 Adults Hospitalized for Cellulitis Readmitted Within a Month

The 30-day rehospitalization rate for adults hospitalized for cellulitis is nearly 10% in the United States, according to a study published online in JAMA Dermatology. Researchers from Harvard Medical School came to their findings after assessing 447,080 hospital admissions for cellulitis using the nationally representative 2014 Nationwide Readmissions Database. Specifically, the analysis identified a 30-day all-cause nonelective readmission rate of 9.8% among the study population. Skin and subcutaneous tissue infections were the most common cause of readmission (29.7%). Read More

First Patients Dosed in Phase 1/2 Trial Testing PTR-01 for Recessive Dystrophic Epidermolysis Bullosa

A Phase 1/2 trial evaluating the investigational therapy PTR-01 for recessive dystrophic epidermolysis bullosa (RDEB) has started dosing patients. PTR-01 is a recombinant version of the human protein collagen type VII (rC7), which is mutated in dystrophic epidermolysis bullosa patients. The therapy, developed by Phoenix Tissue Repair, is administered into the blood and is a potential disease-modifying treatment that works by replacing defective collagen type VII with healthy collagen at sites where it’s needed. Currently, no cure or effective treatment is available for RDEB patients, but this treatment seems to effectively promote wound healing, as seen in mouse models of the condition. Read More

San Antonio’s Burn Treatment Pioneer Basil Pruitt Dies at 88

A retired colonel who led the Army’s Institute of Surgical Research for 27 years, he studied why burn wounds become infected and, with the ISR laboratory division chief, the late Arthur D. Mason Jr., developed and tested a cream that reduced that risk. At the institute, Pruitt created a model in which rigorous scientific inquiry was followed by dramatic improvements in care that were shared with civilian burn centers worldwide. Burn patients now have a far better chance of survival than they did 50 years ago. “The one word which comes to mind when thinking of Dr. Basil A. Pruitt Jr. is ‘giant,’” Dr. Lee Cancio, a retired Army colonel and now civilian director of the ISR’s burn center at Joint Base San Antonio-Fort Sam Houston, said Monday. Read More

Is Tendon Lengthening Underused for Diabetic Foot Problems?

Diabetes mellitus causes sensory and motor neuropathy. Neuropathy in patients with diabetes results in decreased protective sensation and tendon imbalance. Tendon imbalance, especially Achilles or gastrocnemius-soleus tightness, causes increased mechanical stress in the foot. This stress can cause foot pain and calluses, which can progress to forefoot ulcers. Less commonly, the increased stress in the foot causes the bone and ligaments of the foot to fail before the skin, resulting in the arch collapse of Charcot foot. Arch collapse can progress to plantar bony prominence and then midfoot ulceration. This increased stress in the foot can be decreased by tendon lengthening, which can resolve foot pain and ulcers. Read More