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Featured Articles

  • September 17, 2019

    Failed Cancer Drug Looks Promising for Scleroderma and Other Fibrotic Conditions 

    Sixteen years ago, a research group at Mayo Medical School published results showing that a protein called TRAIL can kill cells that cause liver fibrosis but no one seemed to follow up on these findings. Now, researchers at Johns Hopkins Medicine have improved on this protein and shown that it selectively kills cells that cause the hardening of skin associated with scleroderma, effectively reversing the condition in mice genetically engineered to mimic the disease. A report on these results was published earlier this year in Nature Communications.  Read More  

    Novel Approach Leads to Potential Sepsis Prevention in Burn Patients  

    Immediately following severe burns, bacteria reach the wound from different sources, including the patient's skin, gastrointestinal tract, respiratory tracts and health care-related human contact. Within the wound, bacteria multiply, establish an infection and move from the infected burn wound into the bloodstream, causing serious complications like sepsis, multiple-organ failure and death. Read More

    How Lymphoma Cells Metastasize to the Brain

    Lymphomas in the central nervous system are rare but dangerous. Scientists at the German Cancer Research Center (DKFZ) have now discovered which molecular mechanism leads to lymphomas forming metastases in the central nervous system. Using a mouse model, the researchers showed that chronic inflammatory processes in aging brains lead to lymphoma cells that have entered the brain tissue being retained instead of being released directly back into the blood. They also identified key molecules of this mechanism in tissue samples from patients with lymphomas of the central nervous system.  Read More

    AI-Based Algorithm May Predict Nonmelanoma Skin Cancer in High-Risk Patients

    A nonmelanoma skin cancer risk prediction model using readily available information in the electronic medical records system and a deep learning approach appeared to demonstrate robust discrimination, according to findings published in JAMA Dermatology. “This machine learning-based prediction tool may facilitate determination of which patients are likely to develop [nonmelanoma skin cancer]. Read More

  • September 10, 2019

    Novel Approach Leads to Potential Sepsis Prevention in Burn Patients

    Immediately following severe burns, bacteria reach the wound from different sources, including the patient's skin, gastrointestinal tract, respiratory tracts and health care-related human contact. Within the wound, bacteria multiply, establish an infection and move from the infected burn wound into the bloodstream, causing serious complications like sepsis, multiple-organ failure and death.  Read More  

    How Cellulitis Can Be Treated  

    Cellulitis is an infection of the skin that typically happens after a break in the integrity of the skin. A break in the skin can be something as small as a paper cut or a similar wound or could be a crack in dry skin. Essentially, any break in the skin can become a doorway for bacteria to enter and create an infection in the skin. Surgery patients often have large or multiple incision sites where cellulitis can develop after their procedure, making proper wound care especially important until the wound is completely healed. Read More

    Some Hospital-Acquired Pressure Injuries Are Unavoidable

    Joyce Pittman, Ph.D., R.N., from the University of South Alabama in Mobile, and colleagues conducted a descriptive, retrospective study to examine the proportion of HAPIs among patients in critical and progressive care units that are unavoidable and to determine risk factors that differentiate avoidable from unavoidable HAPIs. Data were included for 165 patients.  Read More

    Is Health Literacy Linked With Diabetic Foot Outcomes?

    Results of a systematic review on health literacy in people with diabetic foot disease has recently been presented in the prestigious Diabetic Medicine journal and at the 8th International Symposium on the Diabetic Foot held at The Hague in May this year. This large review investigated the association between health literacy and diabetic foot disease outcomes and was led by the University of Tasmania’s Pam Chen. Read More

  • September 3, 2019

    Sepsis and Pressure Ulcers: Infected Sores Can Lead to Sepsis

    Pressure ulcers, skin sores, have always been a problem for people who must stay in bed for extended periods and those who use wheelchairs for mobility. It is one of the first things nursing students are taught about patient care because, depending on a patient’s health, skin breakdown can begin in hours. Pressure ulcers can also occur for other reasons. For example, ill-fitting shoes can cause rubbing and sores and someone who has a leg or arm amputation could develop a pressure ulcer where the limb meets their prosthetic. The cause for pressure ulcers is simple: pressure on the skin prevents blood flow to the tissue. This blood flow is essential because it brings oxygen and nutrients to the skin to nourish it and keep it healthy. The longer the pressure is present and the harder the pressure, the more blood is prevented from circulating.  Read More  

    Once Considered Rare, an Itchy Dermatologic Skin Disorder Is More Common Than Thought  

    Johns Hopkins researchers report that prurigo nodularis (PN), a skin disease characterized by severely itchy, firm bumps on the skin, may be associated with other inflammatory skin disorders as well as systemic and mental health disorders. Compared with other skin diseases, however, not much is known about PN. While symptoms of PN can be managed, no cures exist.  Read More

    Diagnosing Adult-Onset Atopic Dermatitis

    To better diagnose, treat and manage adult-onset atopic dermatitis, dermatologists should know important differences between the disease when it starts in adulthood, versus in childhood, according to a Grand Rounds Review on adult-onset atopic dermatitis published January 2019 in the Journal of Allergy and Clinical Immunology: In Practice. Twenty-five percent of adults with atopic dermatitis report the disease started in adulthood. Yet, diagnosing adult-onset atopic dermatitis can challenge even expert clinicians because these patients may present with different lesional morphology and distribution than children with atopic dermatitis. And adult-onset atopic dermatitis has a much broader differential diagnosis of eczematous disorders than child-onset disease, according to the paper.  Read More

    Preventing Cancer-Related Lymphedema

    Advances in medical treatment have dramatically improved cancer care and survivorship. However, of the nearly 17 million cancer survivors living in the U.S., it is estimated that one in three of those treated for the cancers below will develop lymphedema. Those most at risk are patients who undergo surgery, radiation therapy or Taxane-based chemotherapy to treat: Breast cancer, Colorectal cancer, Melanoma, Genital cancers, Urinary cancers.  Read More

  • August 27, 2019

    Blocking Inflammatory Pathway Key to Preventing Brain Metastasis from Melanoma

    A new Tel Aviv University study finds that melanoma brain metastasis occurs when tumor cells "hijack" an inflammatory pathway in the brain. Blocking this pathway could prevent these metastases from developing, according to the research. "The prognosis of patients with brain metastases is very grim," explains Prof. Neta Erez of the Department of Pathology at TAU's Sackler Faculty of Medicine, the lead author of the study. "Patients used to die from metastases in other places before brain metastases were clinically evident.   Read More  

    How to Choose a Cushion for a Wheelchair to Prevent Pressure Ulcers and to Make Sitting Comfortable  

    Can you believe that according to a report made by the World Health Organization (WHO) there are over 650 million people worldwide with a disability, and out of that population; about 10% need to use a wheelchair to support their daily life? The stats show how commonly we may need a wheelchair to support us, our family or friends. People that make use of wheelchairs need comfort too. It is not a new thing that the type of wheelchair cushions a wheelchair user use influences his or her medical condition and overall well being.  Read More

    Guidelines on Prevention and Management of Pressure Ulcers

    The purpose of these guidelines is to ensure that persons with a pressure ulcer, or who are at risk of developing pressure ulcers when using their wheelchairs, are appropriately assessed by the physiotherapist (or other appropriated health care professional) and are prescribed the most suitable equipment. A pressure ulcer is ‘a localized injury to the skin and/or underlying tissue usually over a bony prominence, as a result of pressure, or pressure in combination with shear. Whilst pressure ulcers are more likely to affect older people, it is now accepted that people of all ages may be affected, therefore the principles of these guidelines apply to beneficiaries of all age groups.  Read More

    Study Compares Investigational Regenerative Skin Tissue to Conventional Treatment for Severe Burns

    Autografting is considered to be the standard of care for severe burns. The process involves the surgical harvesting of healthy skin from an uninjured site on the patient and transplanting the skin graft to the injury, resulting in two wounds that require care. Not only do patients experience increased pain, but both the burn injury site and the donor site are at increased risk of infection, scarring and impaired skin function.  Read More

  • August 20, 2019

    Ionizing Radiation May Damage Stem Cells ‘Critically Involved in Wound Healing'

    In situ damage to skin-derived mesenchymal stem cells during neoadjuvant or adjuvant radiotherapy appeared to have a significant effect on the pathogenesis of slow or nonhealing radiation wounds, according to study findings published in Stem Cells Translational Medicine. “Although effective in the treatment of solid tumors, radiotherapy produces a number of off-target effects in the overlying skin,” Alex K. Wong, MD, reconstructive surgeon in the division of plastic and reconstructive surgery at Keck School of Medicine of USC, and colleagues wrote. “These changes result in skin that responds poorly to wounding by trauma or surgery, predisposing to the development of chronic wounds.”  Read More  

    New Biodegradable Wound Dressing Developed 

    Researcher Abhishek Gupta, of the University of Wolverhampton's School of Pharmacy, developed the new innovative dressings. He said they would provide an alternative to conventional gauze, which could be particularly beneficial for immunocompromized patients such as HIV patients, diabetics and the elderly. They can be used for dry or exudative wounds as they are capable of creating a moist microclimate at the wound site which facilitates healing. Read More

    Long-Term Dupilumab Treatment Safe, Effective for Atopic Dermatitis

    Dupilumab showed consistent and sustained efficacy in an open-label extension study in adults previously enrolled in 12 parent studies assessing dupilumab in moderate to severe atopic dermatitis. “More than half of patients did not require additional treatment for [atopic dermatitis] during the treatment period,” Mette Deleuran, MD, DMSc, of Aarhus University Hospital in Denmark, and colleagues wrote. “This, combined with the relatively small numbers of patients requiring systemic rescue therapy, supports that dupilumab monotherapy or concomitant with topical [atopic dermatitis] medications provides long-term disease control in moderate to severe [atopic dermatitis] patients.”  Read More

    New Pain Organ Discovered in the Skin

    Researchers at Karolinska Institutet in Sweden have discovered a new sensory organ that is able to detect painful mechanical damage, such as pricks and impacts. The discovery is being published in the journal Science. Pain causes suffering and results in substantial costs for society. Almost one person in every five experiences constant pain and there is a considerable need to find new painkilling drugs. However, sensitivity to pain is also required for survival and it has a protective function.  Read More

  • August 12, 2019

    Cellular Engines of Wound Repair Have Distinct Roles

    Following tissue injury, fibroblast cells activate, divide and play key roles in both tissue repair and pathological scarring—fibrosis—that can drive organ failure. Vanderbilt investigators have now discovered that, in contrast to prevailing dogma, fibroblasts are not all alike; instead, they have distinctive functions following tissue injury. "Our work offers a new perspective over the currently held thinking that fibroblasts are a single population of cells working in the same manner to coordinate wound repair," said Pampee Young, MD, Ph.D., adjunct professor of Pathology, Microbiology and Immunology.  Read More  

    Discordant Themes Exist in Skin Cancer Assessment Outcomes Among Physicians, Patients 

    Areas of disagreement between patients and physicians on skin cancer-related outcomes include patient fear of the unknown, recurrence and empowering patients to make treatment choices, according to researchers in Dermatologic Surgery. “The shift from a physician/disease-specific point of view to a patient-oriented one has created a new set of qualitative outcomes,” Anthony M. Rossi, MD, of the dermatology service at Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College in New York, and colleagues wrote. Read More

    Researchers Identify Barriers to Fungal Infection Diagnosis

    There are several barriers that prevent the consistent use of fungal diagnostic preparations to correctly identify cutaneous fungal infections, according to a survey from a team at the George Washington University (GW). The study is published in the Journal of Drugs in Dermatology. Cutaneous fungal infections account for between 3.5 and 6.5 million dermatologist office visits per year. Despite their frequency, the diverse presentations of fungal infections often lead to misdiagnosis, resulting in additional costs, time, and delays in proper care. Read More

    Heat-Activated Wound Dressing Has Potential to Heal Chronic Wounds, Pressure Sores

    Active adhesive dressing technology was created by Harvard biomedical engineers.Biomedical engineers said they have created a new wound dressing that contracts in response to body heat, is stretchy, adhesive, antimicrobial and helps to speed healing. The material, called active adhesive dressing, closes wounds “significantly faster” than other commonly used materials and prevents bacterial growth without the need for additional apparatus, the engineers reported. Read More