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Featured Articles

  • July 5, 2017

    Inflammatory Bowel Disease: Scientists Zoom in on Genetic Culprits

    Scientists have closed in on specific genes responsible for Inflammatory Bowel Disease (IBD) from a list of over 600 genes that were suspects for the disease. The team from the Wellcome Trust Sanger Institute and their collaborators at the Broad Institute of MIT and Harvard and the GIGA Institute of the University of Liège combined efforts to produce a high resolution map to investigate which genetic variants have a causal role in the disease.  Read More

    U Team Discovers 'Powerhouse' New Treatment in Fight Against Deadly Skin Disease

    A decade after performing the world's first bone marrow transplants to treat epidermolysis bullosa − a rare and potentially fatal skin disease − university researchers believe they have discovered a "powerhouse" new formula that advances their research, helps the body grow new skin and will allow patients to live longer, less painful lives.  Read More

    In Major Breakthrough, Tiny Utah Firm Regenerates Skin, Hair in Pigs

    A small U.S. biotech has successfully regenerated skin and stimulated hair growth in pigs with burns and abrasions, paving the way for a scientific breakthrough that could lead to the regeneration of fully functional human skin. Salt Lake City-based PolarityTE Inc's patented approach to tissue engineering is designed to use a patient's own healthy tissue to re-grow human skin for the treatment of burns and wounds. Despite recent advances in reconstructive surgery, plastic surgeons cannot give burn victims what they require the most - their skin.  Read More

  • June 27, 2017

    Fish Skin for Human Wounds: Iceland's Pioneering Treatment

    The market for skin substitutes isn't for the squeamish. Rival products include material from pig intestines, fetal cows, the innermost layer of human amniotic tissue, and cadavers. It can be tough to compare medical outcomes, as clinical trials are small and disease-specific. But generally, because of the viral disease transfer risk, human- and animal-derived products require heavy processing and tend not to work well in infected wounds. That's one of Kerecis's talking points, as the only FDA-approved skin substitute derived from fish: Because of our evolutionary differences, there's less disease risk and therefore less processing required. Read More

    Necrotic Wound Causes and Symptoms

    Tissue necrosis involves various causes. According to Wound Source, these include infection, toxins, and trauma. In anatomy and physiology, cells that die signal phagocytes to ingest dead cells; however, in tissue necrosis, as per the publication, cells that die due to necrosis fail to signal adjacent phagocytes to ingest the dead cells; this result to the accumulation of dead tissue and cell debris. Other causes of tissue necrosis include infarction, inflammation, poison, and cancer, among others.  Read More

    In India, 85% of Diabetics Face Amputation; Doctors Explain Why it is so Common

    Going by the numbers, globally, there are around 415 million people suffering from diabetes; India being the second largest with 69 million. Furthermore, almost 15 percent of diabetics develops an ulcer in their lifetime and around 85 percent faces amputations. These figures were announced at the national level conference on 'Wound Healing' organised by Zen Hospital, Mumbai. To counter the epidemic, most hospitals and institutions have started diabetes management and education programmes. Still, one area that remains grossly neglected and ignored is diabetic foot care.  Read More

  • June 20, 2017

    Researchers Develop New Method to Treat Rare Skin Disease

    Research by University of Minnesota doctors is helping patients with a blistering skin condition grow stronger through bone marrow transplants. University researchers have been developing a new method since 2007 to treat Epidermolysis Bullosa, a disorder that causes theskin to tear at the slightest touch. The therapy uses a bone marrow transplant, replacing dysfunctional stem cells in the patient's body with functional ones helping to hold skin tissue together, said Jakub Tolar, the project's lead and the executive vice dean of the University's Medical School.  Read More

    Parts Science, Humanity

    According to the Wound Ostomy and Continence Nurses Society, roughly 80% of individuals affected by urinary incontinence can be cured or improved. Yet in their zeal to manage incontinence, many providers unwittingly trade one potential problem for another by relying on medications that pose cognitive risk or poorly made briefs that could contribute to bedsores. But much progress is being made to reduce or even eliminate at least some forms of incontinence that not only could positively impact a facility's bottom line through greater staff efficiencies and reduced liability but also by restoring residents' dignity and independence.  Read More

    Health-Related Quality of Life and Sleep Disorders in Patients With a Urostomy: Is There a Relationship?

    The purpose of this study was to evaluate the relationship between health-related quality of life (HRQOL) and sleep disorders in persons living with a urostomy. Eighty-six adults with a urostomy who were cared for in a stoma outpatient clinic of a hospital in Osaka, Japan, for at least 1 month before data collection, and who were attending support group meetings comprised the sample. The majority of participants were diagnosed with bladder cancer; the median time since ostomy surgery was 3.7 years. Study findings suggest that persons with a urostomy have lower HRQOL and sleep quality than adults in the general population.  Read More  

    Week 2 Scleroderma Awareness Month: Patient Profiles 2017, Progress in Medical Research

    In relation to the cause of scleroderma, due to the disease belonging to the autoimmune family, research understanding is focused around the immune response with various cytokines (chemical substances) acting as biomarkers. So, in essence, the higher the level of the biomarker, the more aggressive/active the disease. Further studies are required to confirm this understanding more, as well as to identify all biomarkers involved. This approach is very encouraging for determining a speedy timely diagnosis, in the hope to prevent any life-threatening damage, while keeping treatments options available.  Read More

  • June 13, 2017

    Effect of Lymphedema Treatment for Management of Acute Pilon Fractures

    Patients who have suffered a length-unstable pilon fracture are routinely staged with an external fixator to stabilize the ankle until the surrounding soft tissue is amenable for surgery, generally between 10 days and 3 weeks. Coupled with delaying surgical intervention, posttraumatic edema also increases the risk of wound complications and postoperative infections. Because pilon fractures have alarmingly high complication rates, it has been suggested that soft tissue management is as important as the bony reconstruction, further highlighting the need to control and reduce swelling in the affected limbs.  Read More

    Ulcers: Closing the Gaps

    More than 25% of seniors age 65 and older have diabetes, and as many as 34% of nursing home residents battle the disease - a rate higher than any other population. Diabetes can damage organs, diminish vascular and arterial health, and cause neuropathy that raises the risk for ulcers, amputations and death. Some studies have shown roughly 1 in 5 infected foot ulcers lead to amputation, and the mortality rate for those with a lower-extremity amputation is just two to five years.  Read More

    Advances in Wound Healing Treatment May Help Diabetics

    Cell therapy has provided a new avenue for treatment care in diabetic patients and skin repair as a whole. This form of therapy involves modifying white blood cells-the cells that fight infection-to accelerate the healing process. Normally, white blood cells play a vital role in normal wound healing. By maintaining the balance between inflammation and anti-inflammatory reactions, white blood cells promote tissue repair and cellular clean up. By using these modified macrophages, the researchers could heal lesions much more quickly by using a newly developed treatment called adaptive cell transfer. Read More  

  • June 6, 2017

    Wound Care Awareness Week is June 5-9

    The fourth annual Wound Care Awareness Week is being held June 5-9. One of nearly 800 Healogics-managed centers, UVMC offers advanced therapies to patients suffering from chronic wounds. Program directors across the nation will dedicate the entire week to educating physicians, patients and the general public about the chronic wound epidemic and the advanced wound care solutions.  Read More

    Personalizing Wound Care to Educate and Drive Patient Comprehension

    Applying wound care dressings can be complex, frustrating, and frankly a bit scary. The process of changing dressings doesn't have to be complicated. However, many times an individual's lack of understanding can create barriers to successful treatment and healing. Education and retention on how to care for their wounds will reduce the need for follow-up calls and, potentially, complications from chronic open wounds.  Read More

    Adherence to Lipid-Management Guidelines Benefits Patients with CLI

    Patients undergoing revascularization for critical limb ischemia had better mortality and major adverse limb event outcomes if they adhered to the statin intensity recommended in the 2013 American College of Cardiology/American Heart Association lipid-management guidelines, researchers reported. The researchers conducted a retrospective analysis of all patients who underwent first-time endovascular or surgical revascularization for CLI - also called chronic limb-threatening ischemia. Read More  

  • May 31, 2017

    Healing Wounds with Cell Therapy

    An experimental treatment in mice allows the reprogramming of blood cells in order to promote the healing process of cutaneous wounds. This approach could prove to be beneficial in healing challenging wounds in diabetics and major-burn victims. Diabetic patients frequently have lesions on their feet that are very difficult to heal due to poor blood circulation. In cases of serious non-healing infections, a decision to amputate could be made. A new therapeutic approach, presented recently in the Journal of Investigative Dermatology by Canadian researchers affiliated with the University of Montreal Hospital Research Centre (CRCHUM), could prevent these complications by promoting wound healing. Read More

    Exploring the Influence of a Cooling Treatment on Quality of Life in Patients with Chronic Venous Disease

    The purpose of this study was to determine whether quality of life (QOL) was affected by the use of a cooling cuff to reduce negative symptoms of chronic venous disease (CVD) of the lower legs where the skin was previously ulcerated and/or damaged. Individuals participating in the study received one of two treatments: a cooling cuff made of gel or a "placebo" cuff filled with cotton. The cuffs were kept in the freezer until they were ready to be applied to the affected skin, starting daily for 30 minutes for 30 days, then twice-weekly for 3 months and then weekly for 3 months.  Read More

    A Quarter of Nursing Home Residents are Colonized with Drug-Resistant Bacteria

    The significant presence of multidrug-resistant gram-negative bacteria (MDR-GNB), such as E. coli, among nursing home residents demonstrates the need for heightened infection control prevention and control measures in nursing homes, according to a meta-analysis published in the May issue of the American Journal of Infection Control, the official journal of the Association for Professionals in Infection Control and Epidemiology (APIC). Read More