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Featured Articles

  • January 31, 2018

    Collagen VII Protein Important in Immune Response to Bacteria in EB, Mouse Study Shows

    The systemic administration of collagen VII protein can reduce bacteria in the skin of mice with epidermolysis bullosa (EB), according to a report published in the journal Proceedings of the National Academy of Sciences. The study, “Impaired lymphoid extracellular matrix impedes antibacterial immunity in epidermolysis bullosa,” showed that collagen VII is required in the spleen to support the activity of immune cells and promote their innate defense mechanisms. This finding may help researchers understand why people with epidermolysis bullosa, a rare genetic disease caused by a mutation in the COL7A1 gene — which provides instructions for the protein collagen VII — are more susceptible to developing wound infections. The results may also open new therapeutic avenues to treat EB. Read More

    People With Diabetes Face Increased Risk of Infections

    Diabetes patients have an increased risk of suffering serious infections or death compared to the general public, new research has shown. The study analysed the electronic GP and hospital records of more than 100,000 adults aged 40 to 89 years with a diabetes diagnosis, and compared them to those without a diabetes diagnosis. The researchers estimated that 6% of infection-related hospital admissions, such as for pneumonia, and 12% of infection-related deaths among adults could be attributed to diabetes. Read More

    Iran Unveils Indigenous Polymer Wound Care Dressing, Artificial Vessel

    Iranian scientists have managed to produce an artificial vessel and a type of wound care dressing using polymeric materials. The two technological developments were unveiled in a ceremony attended by the Head of Iran Polymer and Petrochemical Institute (IPPI) Mehdi Nekouhesh. The polymer wound care dressing was invented as part of larger plan to find a treatment for a particular type of skin wounds, a Farsi report by Mehr said. The artificial vessel was the second invention of the Institute’s scientists. The vessel, which is now at the clinical stage, used to be an imported good and is being produced for the first time by IPPI in Iran. Read More

    A Powerful new Weapon Against Drug-Resistant Bacteria was Inspired by the Human Body

    Drug-resistant bacteria are thwarting the world’s last-resort antibiotics, leading scientists to seek new compounds from poisonous frogs, backyard soil bacteria, and other wildlife. Now, scientists have found the makings of an exceptional microbe killer inside us: By tweaking a naturally occurring peptide—a short chain of amino acids—found in the human body, researchers have designed a drug that could wipe out obstinate microbes resistant to all available treatments. When a small subset of bacteria survives antibiotic treatment, an infection can get out of control fast. As these resilient microbes thrive, they can group together on a surface—like a wound or a medical device—and encase themselves in a slimy protective layer known as a biofilm.  Read More

  • January 24, 2018

    Clinical Education Available On-Demand!  "Preventing Surgical Site Infections: Implementing a Multidisciplinary Evidence-Based Strategy."

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    Eye Exam Might Help Spot Poor Circulation in Legs

    Could a routine eye exam some day point to trouble with circulation in the legs? New research suggests it might be possible. Researchers at Johns Hopkins University in Baltimore said changes in the eye's retina may help spot people at risk for a narrowing of the large blood vessels in the legs -- a condition called peripheral artery disease (PAD). After adjusting for common PAD risk factors such as diabetes, the researchers found that people with abnormalities in the tiny blood vessels of the retina had more than double the odds of developing PAD, and nearly 3.5 times the odds of developing its more severe form, critical limb ischemia. Read More

    Pneumatic Compression Promising for Lymphedema

    One treatment session with advanced pneumatic compression is associated with reduced cancer-related head and neck lymphedema. Head and neck lymphedema is a frequent complication of treatment for cancers of the head and neck. Head and neck cancer and its treatment by surgical interventions and/or radiotherapy may obstruct or disrupt lymphatic vessels and damage surrounding soft tissue. The lymphatic disruption and tissue damage leads to an accumulation of fluid in the affected areas. This protein-rich fluid activates chronic inflammatory responses resulting in progressive skin and subcutaneous tissue fibrosis further impairing lymphatic function. Although head and neck lymphedema is associated with substantial symptom burden, functional deterioration, and poor quality of life, it remains underrecognized and undertreated. Read More

    Patient Outcomes After Revascularization Improve in UK

    From 2006 to 2015, overall survival increased and the risk for lower-limb amputation decreased after revascularization in patients with peripheral artery disease in the United Kingdom. The availability of revascularization procedures has changed during the past decade (2006-2015), and with recent developments in endovascular and surgical technology, particularly stents and drug-eluting technologies, less invasive procedures have become more widely used in the United Kingdom and elsewhere. Read More

    Equine Stem Cells May Rein in Bacteria in Skin Wounds

    Researchers with the Cornell University College of Veterinary Medicine are exploring the use of stem cells to treat skin wounds in horses with techniques that may eventually translate into the treatment of human patients. Bacteria often complicate the treatment of chronic skin wounds in people, driving a need for new therapies that reduce bacteria in wounds. Although previous research has explored the therapeutic value of MSCs in healing, few studies have examined the potential for MSCs to inhibit bacterial growth. Read More

    Microbes On The Skin Of Mice Promote Tissue Healing, Immunity

    Beneficial bacteria (link is external) on the skin of lab mice work with the animals’ immune systems to defend against disease-causing microbes and accelerate wound healing, according to new research from scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. Researchers say untangling similar mechanisms in humans may improve approaches to managing skin wounds and treating other damaged tissues. Read More

     

  • January 17, 2018

    Clinical Education Available On-Demand!  "Preventing Surgical Site Infections: Implementing a Multidisciplinary Evidence-Based Strategy."

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    TCMH is Testing Ground for New Wound Therapy Technology

    Mirragen, developed by Missouri Science and Technology student and ceramic engineer Steve Jung, is a bioactive resorbable glass fiber technology that has been found to help wounds heal faster. As a glass fiber, Mirragen can also be used for wounds with challenging geometries. Bioactive glass has been used since the 1960s to grow bone tissue. The silica used in bioactive glass was not a suitable product for growing soft tissue, but Jung used boron in a glass fiber that was found to help heal soft tissue. The borate-based fiber is sturdy and durable for a period of time, but it also breaks down and dissolves as soft tissue heals. Read More

    FDA Grants Marketing Permission for Diabetic Foot Ulcer Treatment Device

    The FDA has permitted the marketing for the first shock-wave device for the use of treating diabetic foot ulcers, according to an agency press release. The device is intended for treatment of chronic, full-thickness diabetic foot ulcers with wound areas no larger than 16 cm2 extending through the epidermis, dermis, tendon or capsule, without bone exposure. The device is an external system that employs pulses of energy to stimulate the wound and is intended for use in adults aged at least 22 years with diabetic foot ulcers of more than 30 days’ duration. The device should be used along with standard care. Read More

    New Molecular Probes to Allow Non-Destructive Analysis of Bioengineered Cartilage

    A new study describes novel probes that enable non-invasive, non-destructive, direct monitoring of the differentiation of mesenchymal stem cells (MSCs) in real-time during the formation of engineered cartilage to replace damaged or diseased tissue. These molecular probes make it possible to assess the quality of the cartilaginous tissue and its suitability for implantation as it is forming, and to make modifications to enhance the multi-step process of MSC differentiation into chondrocytes "on the go". Read More

    An eNose is Able to Sniff out Bacteria that Cause Soft Tissue Infections

    A recent study conducted at the University of Tampere, Tampere University of Technology, Pirkanmaa Hospital District and Fimlab in Finland has concluded that an electronic nose (eNose) can be used to identify the most common bacteria causing soft tissue infections. A recent study conducted at the University of Tampere, Tampere University of Technology, Pirkanmaa Hospital District and Fimlab in Finland has concluded that an electronic nose (eNose) can be used to identify the most common bacteria causing soft tissue infections. Read More

    Science Fiction and Folk Medicine Inspire Novel Wound Dressings

    A relatively inexpensive egg-based formula and a Star Trek-like plasma patch can accelerate healing of serious and chronic wounds. Inspired in part by Star Trek, his favourite show, Dr. Mahrenholz is bringing the sci-fi use of plasma closer to reality by developing an active plasma dressing for treating chronic wounds. But he warns that the current issues we are experiencing with multidrug-resistant bacteria means that we are on the brink of a return to the Middle Ages in terms of our susceptibility to infection. Read More

     

  • January 10, 2018

    Clinical Education Available On-Demand!  "Preventing Surgical Site Infections: Implementing a Multidisciplinary Evidence-Based Strategy."

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    Specialist says Cryopreserved Tissue is 'Game Changer' for Diabetic Foot Ulcers

    Thanks to a cutting-edge treatment, Anton not only kept her toes, but also maintained normal movement in her foot. Grafix, cryopreserved human placental tissue, was applied to the surface of Anton's wound. She also received hyperbaric oxygen therapy, a medical treatment in which patients breathe 100 percent oxygen while under pressure in a hyperbaric chamber, and wore a total contact cast to maximize offloading. Read More

    Leishmaniasis in Humans: Drug or Vaccine Therapy?

    Leishmania is an obligate intracellular pathogen that invades phagocytic host cells. Approximately 30 different species of Phlebotomine sand flies can transmit this parasite either anthroponotically or zoonotically through their bites. Leishmaniasis has been reported as one of the most dangerous neglected tropical diseases, second only to malaria in parasitic causes of death. People can carry some species of Leishmania for long periods without becoming ill, and symptoms depend on the form of the disease. Read More

    Using Mechanical Forces to Improve Wound Healing

    To most, an operating room and a manufacturing plant are as different as any two places can be. But not to Dennis Orgill. Orgill showed for the first time how to regenerate both the epidermis and the dermis of the skin. He developed a process of infusing a collagen skin graft — known as a scaffold — with healthy cells to promote regeneration. When applied to the wound, the cell-infused scaffold was found to promote healing. Read More

    Low-Intensity Workouts Help Wound Healing for Diabetics

    Low-power exercise may be the key to speeding wound healing rates in patients with diabetes, a new study suggests. Previous research showed moderate-intensity exercise to improve wound healing in both mice and human subjects, but little was known about the impact different intensities could have on healing rates. Read More

    Stop the Splashes, Spills: How Hospitals can Ensure Safe Disposal of Infectious Fluid Waste

    For clinical leaders on the front lines of healthcare, keeping patients and staff safe is the No. 1 priority. The products and practices that are utilized to support infection prevention are the same products and practices that support the safety of the employee as care is given. If facilities focus on one goal and not the other, they won't realize the desired outcome for patients and healthcare workers. It's critical in today's environment to always address both. Read More

     

  • January 3, 2018

    Clinical Education Available On-Demand!  "Preventing Surgical Site Infections: Implementing a Multidisciplinary Evidence-Based Strategy."

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    Doctors Mend Cancer Wound With World’s Largest Skin Flap

    A team of doctors at KRIMS hospital, Ramdaspeth reconstructed a wound on a young man's face using perhaps world's largest skin flap. The PMMC (pectoralis major myocutaneous) flap, as it is technically called, was taken from right side of patient's chest and used for facial reconstruction on the wound of patient who has cancer in a severe stage. Read More

    A Risk Factor for Drug-Induced Skin Disease Identified

    Researchers have identified a type of human leukocyte antigen (HLA) that is associated with the skin disease bullous pemphigoid (BP) in diabetic patients administered with DPP-4 inhibitory drugs. DPP-4 inhibitor (DPP-4i) is widely used to treat type 2 diabetes, but increased cases of bullous pemphigoid (BP) have been reported among patients taking the medicine. BP is the most common autoimmune blistering disorder, characterized by itchy reddening of the skin as well as tense blisters over the whole body. Read More

    Researchers Create Unique Bioengineered Organoids for Modeling Colorectal Cancer

    A new study describes a unique bioengineered tissue construct, or organoid, into which colorectal cancer cells are embedded, creating a model of the tumor and surrounding extracellular matrix (ECM). The authors propose that in the future these organoids could be made using a patient's own cells for personalized medicine applications. Read More

    Can Probiotics Help Relieve Atopic Dermatitis Symptoms?

    A new randomized clinical trial published in JAMA Dermatology explores the effectiveness of oral probiotics in treating atopic dermatitis. Atopic dermatitis is a chronic inflammatory skin disease estimated to occur in up to 20% of children around the world. In addition to recurrent bouts of intense inflammation and itching, children with atopic dermatitis are more likely to develop other disorders such as asthma and chronic sinusitis. Read More

    Nurses Should Practice Pressure Ulcer Prevention

    Pressure ulcer or injury prevention remains one of the most common and significant tasks in healthcare for decreasing harm. We would much rather prevent injury than watch a patient live through preventable pain, wounds or diagnoses. A paradigm shift is in progress toward education efforts in communities to help people maintain or achieve healthy lifestyles so preventable conditions are avoided. Read More

     

  • December 19, 2017

    Clinical Education Available On-Demand!  "Preventing Surgical Site Infections: Implementing a Multidisciplinary Evidence-Based Strategy."

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    The Future of Measuring Patient Safety

    There are at least 57 sessions at the IHI National Forum in Orlando this year that include the words "measure" or "measurement." Clearly there is strong interest in quantifying the results of our efforts to improve the quality of health care. But are we measuring what matters most to keep our patients safe from harm? Or is too much of our attention determined by the hope of incentives and fear of penalties? Read More

    Scientists Discover Metformin As The Optimal Anti-Aging Reagent To Improve Wound Healing

    Cutaneous wounds are one of the most common soft tissue injuries and usually are particularly hard to heal in aging. Recently, a team from Research and Development Center for Tissue Engineering at the Fourth Military Medical University of China identified the topical application of Metformin as the promising pharmacological approach to treat wound defects of both young and aged skin. They hope that this discovery will lead to one feasible cure of nonhealing wounds, particularly in patients with the advancing age. Read More

    Scientists Devise New Treatment for Diabetic Wounds

    Scientists from the Indian Institute of Technology- Madras, Chennai and CSIR- Central Leather Research Institute, Adyar, Chennai have developed a new drug combination to effectively treat diabetic wounds. A dressing of the wounds using the combination drug also revealed and increase in vascularisation- process by which new blood vessels are formed, while also increasing the recruitment of macrophages- a type of white blood cell that protects from infections. Read More

    Doctors Discover New Method to Heal Painful Diabetic Ulcers Using a Jab of 'Muffin Top' Fat

    The dreaded muffin top is the bane of many people's lives - an unsightly roll of flab that spills over the top of trousers or a skirt. But now doctors have discovered an ingenious use for the excess fat - they are using it in injections for painful foot ulcers that are difficult to treat. The technique, which results in rapid healing of the ulcer, has been found to be particularly effective among diabetic patients. Read More