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Could a routine eye exam some day point to trouble with circulation in the legs? New research suggests it might be possible. Researchers at Johns Hopkins University in Baltimore said changes in the eye's retina may help spot people at risk for a narrowing of the large blood vessels in the legs -- a condition called peripheral artery disease (PAD). After adjusting for common PAD risk factors such as diabetes, the researchers found that people with abnormalities in the tiny blood vessels of the retina had more than double the odds of developing PAD, and nearly 3.5 times the odds of developing its more severe form, critical limb ischemia. Read More
One treatment session with advanced pneumatic compression is associated with reduced cancer-related head and neck lymphedema. Head and neck lymphedema is a frequent complication of treatment for cancers of the head and neck. Head and neck cancer and its treatment by surgical interventions and/or radiotherapy may obstruct or disrupt lymphatic vessels and damage surrounding soft tissue. The lymphatic disruption and tissue damage leads to an accumulation of fluid in the affected areas. This protein-rich fluid activates chronic inflammatory responses resulting in progressive skin and subcutaneous tissue fibrosis further impairing lymphatic function. Although head and neck lymphedema is associated with substantial symptom burden, functional deterioration, and poor quality of life, it remains underrecognized and undertreated. Read More
From 2006 to 2015, overall survival increased and the risk for lower-limb amputation decreased after revascularization in patients with peripheral artery disease in the United Kingdom. The availability of revascularization procedures has changed during the past decade (2006-2015), and with recent developments in endovascular and surgical technology, particularly stents and drug-eluting technologies, less invasive procedures have become more widely used in the United Kingdom and elsewhere. Read More
Researchers with the Cornell University College of Veterinary Medicine are exploring the use of stem cells to treat skin wounds in horses with techniques that may eventually translate into the treatment of human patients. Bacteria often complicate the treatment of chronic skin wounds in people, driving a need for new therapies that reduce bacteria in wounds. Although previous research has explored the therapeutic value of MSCs in healing, few studies have examined the potential for MSCs to inhibit bacterial growth. Read More
Beneficial bacteria (link is external) on the skin of lab mice work with the animals’ immune systems to defend against disease-causing microbes and accelerate wound healing, according to new research from scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. Researchers say untangling similar mechanisms in humans may improve approaches to managing skin wounds and treating other damaged tissues. Read More